Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy
Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene laherparepvec (T-VEC). Despite the approva...
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doaj-afd585cd86404d14a3eb70869f2bb9ca2020-11-25T01:01:40ZengMDPI AGCancers2072-66942019-09-01119131410.3390/cancers11091314cancers11091314Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer TherapyYingxuan Zhang0Zheyan Fang1Ruizhen Li2Xiaotian Huang3Qiong Liu4Department of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, ChinaDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, ChinaDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, ChinaDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, ChinaDepartment of Medical Microbiology, School of Medicine, Nanchang University, Nanchang 330006, ChinaCancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene laherparepvec (T-VEC). Despite the approval of these two vaccines, most vaccines have been terminated at the clinical trial stage, which indicates that although they are effective in theory, concerns still exist, including low antigenicity of targeting antigens and tumor heterogeneity. In recent years, with new understanding of the biological function and vaccine potential of outer membrane vesicles (OMVs), their potential application in cancer vaccine design deserves our attention. Therefore, this review focuses on the mechanisms, advantages, and prospects of OMVs as antigen-carrier vaccines in cancer vaccine development. We believe that OMV-based vaccines present a safe and effective cancer therapeutic option with broad application prospects.https://www.mdpi.com/2072-6694/11/9/1314cancer vaccinesouter membrane vesiclesantigen carriertherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yingxuan Zhang Zheyan Fang Ruizhen Li Xiaotian Huang Qiong Liu |
spellingShingle |
Yingxuan Zhang Zheyan Fang Ruizhen Li Xiaotian Huang Qiong Liu Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy Cancers cancer vaccines outer membrane vesicles antigen carrier therapy |
author_facet |
Yingxuan Zhang Zheyan Fang Ruizhen Li Xiaotian Huang Qiong Liu |
author_sort |
Yingxuan Zhang |
title |
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy |
title_short |
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy |
title_full |
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy |
title_fullStr |
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy |
title_full_unstemmed |
Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy |
title_sort |
design of outer membrane vesicles as cancer vaccines: a new toolkit for cancer therapy |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-09-01 |
description |
Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene laherparepvec (T-VEC). Despite the approval of these two vaccines, most vaccines have been terminated at the clinical trial stage, which indicates that although they are effective in theory, concerns still exist, including low antigenicity of targeting antigens and tumor heterogeneity. In recent years, with new understanding of the biological function and vaccine potential of outer membrane vesicles (OMVs), their potential application in cancer vaccine design deserves our attention. Therefore, this review focuses on the mechanisms, advantages, and prospects of OMVs as antigen-carrier vaccines in cancer vaccine development. We believe that OMV-based vaccines present a safe and effective cancer therapeutic option with broad application prospects. |
topic |
cancer vaccines outer membrane vesicles antigen carrier therapy |
url |
https://www.mdpi.com/2072-6694/11/9/1314 |
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