Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples.
X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are...
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doaj-afdf23aa94b94f6ab4fcd30719285d0e2020-11-25T00:57:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013701610.1371/journal.pone.0137016Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples.Marian WillnerGabriel FiorMathias MarschnerLorenz BirnbacherJonathan SchockChristian BraunAlexander A FingerlePeter B NoëlErnst J RummenyFranz PfeifferJulia HerzenX-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding Hounsfield units for phase-contrast imaging have been recently introduced, enabling a setup-independent comparison and standardized interpretation of imaging results. Thus far, the experimental values of few tissue types have been reported; these values have been determined from fixated tissue samples. This study presents phase-contrast Hounsfield units for various types of non-fixated human soft tissues. A large variety of tissue specimens ranging from adipose, muscle and connective tissues to liver, kidney and pancreas tissues were imaged by a grating interferometer with a rotating-anode X-ray tube and a photon-counting detector. Furthermore, we investigated the effects of formalin fixation on the quantitative phase-contrast imaging results.http://europepmc.org/articles/PMC4556454?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marian Willner Gabriel Fior Mathias Marschner Lorenz Birnbacher Jonathan Schock Christian Braun Alexander A Fingerle Peter B Noël Ernst J Rummeny Franz Pfeiffer Julia Herzen |
spellingShingle |
Marian Willner Gabriel Fior Mathias Marschner Lorenz Birnbacher Jonathan Schock Christian Braun Alexander A Fingerle Peter B Noël Ernst J Rummeny Franz Pfeiffer Julia Herzen Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. PLoS ONE |
author_facet |
Marian Willner Gabriel Fior Mathias Marschner Lorenz Birnbacher Jonathan Schock Christian Braun Alexander A Fingerle Peter B Noël Ernst J Rummeny Franz Pfeiffer Julia Herzen |
author_sort |
Marian Willner |
title |
Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. |
title_short |
Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. |
title_full |
Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. |
title_fullStr |
Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. |
title_full_unstemmed |
Phase-Contrast Hounsfield Units of Fixated and Non-Fixated Soft-Tissue Samples. |
title_sort |
phase-contrast hounsfield units of fixated and non-fixated soft-tissue samples. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
X-ray phase-contrast imaging is a novel technology that achieves high soft-tissue contrast. Although its clinical impact is still under investigation, the technique may potentially improve clinical diagnostics. In conventional attenuation-based X-ray computed tomography, radiological diagnostics are quantified by Hounsfield units. Corresponding Hounsfield units for phase-contrast imaging have been recently introduced, enabling a setup-independent comparison and standardized interpretation of imaging results. Thus far, the experimental values of few tissue types have been reported; these values have been determined from fixated tissue samples. This study presents phase-contrast Hounsfield units for various types of non-fixated human soft tissues. A large variety of tissue specimens ranging from adipose, muscle and connective tissues to liver, kidney and pancreas tissues were imaged by a grating interferometer with a rotating-anode X-ray tube and a photon-counting detector. Furthermore, we investigated the effects of formalin fixation on the quantitative phase-contrast imaging results. |
url |
http://europepmc.org/articles/PMC4556454?pdf=render |
work_keys_str_mv |
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