A proposed update for the classification and description of bacterial lipolytic enzymes

Bacterial lipolytic enzymes represent an important class of proteins: they provide their host species with access to additional resources and have multiple applications within the biotechnology sector. Since the formalisation of lipolytic enzymes into families and subfamilies, advances in molecular...

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Main Authors:	Thomas C.A. Hitch, Thomas Clavel
Format:	Article
Language:	English
Published:	PeerJ Inc. 2019-07-01
Series:	PeerJ
Subjects:	Lipase Lipolytic enzymes Carboxylesterase Alpha-beta fold Esterase Hydrolase
Online Access:	https://peerj.com/articles/7249.pdf

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spelling	doaj-aff124652e2743c28f6c8aee840b41d22020-11-25T01:17:14ZengPeerJ Inc.PeerJ2167-83592019-07-017e724910.7717/peerj.7249A proposed update for the classification and description of bacterial lipolytic enzymesThomas C.A. Hitch0Thomas Clavel1Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, GermanyFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, GermanyBacterial lipolytic enzymes represent an important class of proteins: they provide their host species with access to additional resources and have multiple applications within the biotechnology sector. Since the formalisation of lipolytic enzymes into families and subfamilies, advances in molecular biology have led to the discovery of lipolytic enzymes unable to be classified via the existing system. Utilising sequence-based comparison methods, we have integrated these novel families within the classification system so that it now consists of 35 families and 11 true lipase subfamilies. Representative sequences for each family and subfamily have been defined as well as methodology for accurate comparison of novel sequences against the reference proteins, facilitating the future assignment of novel proteins. Both the code and protein sequences required for integration of additional families are available at: https://github.com/thh32/Lipase_reclassification.https://peerj.com/articles/7249.pdfLipaseLipolytic enzymesCarboxylesteraseAlpha-beta foldEsteraseHydrolase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thomas C.A. Hitch Thomas Clavel
spellingShingle	Thomas C.A. Hitch Thomas Clavel A proposed update for the classification and description of bacterial lipolytic enzymes PeerJ Lipase Lipolytic enzymes Carboxylesterase Alpha-beta fold Esterase Hydrolase
author_facet	Thomas C.A. Hitch Thomas Clavel
author_sort	Thomas C.A. Hitch
title	A proposed update for the classification and description of bacterial lipolytic enzymes
title_short	A proposed update for the classification and description of bacterial lipolytic enzymes
title_full	A proposed update for the classification and description of bacterial lipolytic enzymes
title_fullStr	A proposed update for the classification and description of bacterial lipolytic enzymes
title_full_unstemmed	A proposed update for the classification and description of bacterial lipolytic enzymes
title_sort	proposed update for the classification and description of bacterial lipolytic enzymes
publisher	PeerJ Inc.
series	PeerJ
issn	2167-8359
publishDate	2019-07-01
description	Bacterial lipolytic enzymes represent an important class of proteins: they provide their host species with access to additional resources and have multiple applications within the biotechnology sector. Since the formalisation of lipolytic enzymes into families and subfamilies, advances in molecular biology have led to the discovery of lipolytic enzymes unable to be classified via the existing system. Utilising sequence-based comparison methods, we have integrated these novel families within the classification system so that it now consists of 35 families and 11 true lipase subfamilies. Representative sequences for each family and subfamily have been defined as well as methodology for accurate comparison of novel sequences against the reference proteins, facilitating the future assignment of novel proteins. Both the code and protein sequences required for integration of additional families are available at: https://github.com/thh32/Lipase_reclassification.
topic	Lipase Lipolytic enzymes Carboxylesterase Alpha-beta fold Esterase Hydrolase
url	https://peerj.com/articles/7249.pdf
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A proposed update for the classification and description of bacterial lipolytic enzymes

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