Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-<em>N</em>-oxide Derivatives as Hypoxic Selective Anti-tumor Agents
A series of 3-aryl-2-quinoxaline-carbonitrile 1,4-di-<em>N</em>-oxide derivatives were designed, synthesized and evaluated for hypoxic and normoxic cytotoxic activity against human SMMC-7721, K562, KB, A549 and PC-3 cell lines. Many of these new compounds displayed more p...
Main Authors: | Yongzhou Hu, Rong Sheng, Xiaowen Liu, Shihao Shangguan, Qing Xia, Yunzhen Hu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2012-08-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/17/8/9683 |
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