Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism

Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism

Summary: Glioblastoma (GBM) may arise from astrocytes through a multistep process involving a progressive accumulation of mutations. We explored whether GBM-derived extracellular vesicles (EVs) may facilitate neoplastic transformation and malignant growth of astrocytes. We utilized conditioned media...

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Bibliographic Details
Main Authors: Ailiang Zeng, Zhiyun Wei, Rosalia Rabinovsky, Hyun Jung Jun, Rachid El Fatimy, Evgeny Deforzh, Ramil Arora, Yizheng Yao, Shun Yao, Wei Yan, Erik J. Uhlmann, Alain Charest, Yongping You, Anna M. Krichevsky
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Biological Sciences
Cell Biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306106

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