Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenet...

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Main Authors: Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi, Hei Sook Sul
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14617-1
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spelling doaj-b00b481391d4487aa57db0dfdc9af5fd2021-05-11T09:03:49ZengNature Publishing GroupNature Communications2041-17232020-02-0111111610.1038/s41467-020-14617-1Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesisJose A. Viscarra0Yuhui Wang1Hai P. Nguyen2Yoon Gi Choi3Hei Sook Sul4Department of Nutritional Sciences & Toxicology, University of CaliforniaDepartment of Nutritional Sciences & Toxicology, University of CaliforniaDepartment of Nutritional Sciences & Toxicology, University of CaliforniaFunctional Genomics Laboratory, University of CaliforniaDepartment of Nutritional Sciences & Toxicology, University of CaliforniaIn response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenetic mechanism.https://doi.org/10.1038/s41467-020-14617-1
collection DOAJ
language English
format Article
sources DOAJ
author Jose A. Viscarra
Yuhui Wang
Hai P. Nguyen
Yoon Gi Choi
Hei Sook Sul
spellingShingle Jose A. Viscarra
Yuhui Wang
Hai P. Nguyen
Yoon Gi Choi
Hei Sook Sul
Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
Nature Communications
author_facet Jose A. Viscarra
Yuhui Wang
Hai P. Nguyen
Yoon Gi Choi
Hei Sook Sul
author_sort Jose A. Viscarra
title Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_short Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_full Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_fullStr Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_full_unstemmed Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_sort histone demethylase jmjd1c is phosphorylated by mtor to activate de novo lipogenesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenetic mechanism.
url https://doi.org/10.1038/s41467-020-14617-1
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AT yuhuiwang histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis
AT haipnguyen histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis
AT yoongichoi histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis
AT heisooksul histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis
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