Decreased uric acid levels in the acute phase of Plasmodium vivax malaria

Decreased uric acid levels in the acute phase of Plasmodium vivax malaria

Abstract INTRODUCTION Uric acid is one of the compounds associated with the inflammatory process in malaria. It acts as an indicator of cellular damage by activating the immune response and inflammatory process. METHODS: We measured serum concentrations of uric acid in 60 symptomatic patients be...

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Bibliographic Details
Main Authors: Luciano Teixeira Gomes, Ananda Karla Bellei, Denise Inácio de Andrade, Priscila Zanini Gotardo, Andreia Ferreira Nery, Cor Jesus Fernandes Fontes
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019-05-01
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Malaria
Uric acid
Acute phase
Convalescent phase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100649&lng=en&tlng=en
Description
Summary:Abstract INTRODUCTION Uric acid is one of the compounds associated with the inflammatory process in malaria. It acts as an indicator of cellular damage by activating the immune response and inflammatory process. METHODS: We measured serum concentrations of uric acid in 60 symptomatic patients before and after treatment for malarial infections caused by Plasmodium vivax. RESULTS: Lower serum concentrations of uric acid were found during the acute phase of P. vivax malaria compared to those in its convalescent phase (p < 0.0001). CONCLUSIONS: Patients in the acute phase of malaria had lower uric acid levels than those in its convalescent phase.
ISSN:1678-9849

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