Molecular Mechanism Study on Stereo-Selectivity of α or β Hydroxysteroid Dehydrogenases

Molecular Mechanism Study on Stereo-Selectivity of α or β Hydroxysteroid Dehydrogenases

Hydroxysteroid dehydrogenases (HSDHs) are from two superfamilies of short-chain dehydrogenase (SDR) and aldo–keto reductase (AKR). The HSDHs were summarized and classified according to their structural and functional differences. A typical pair of enzymes, 7α–hydroxysteroid dehydrogenase (7α–HSDH) a...

Full description

Bibliographic Details
Main Authors:	Miaomiao Gao, Kaili Nie, Meng Qin, Haijun Xu, Fang Wang, Luo Liu
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Crystals
Subjects:	hydroxysteroid dehydrogenases short-chain dehydrogenase superfamily aldo–keto reductases superfamily stereospecificity
Online Access:	https://www.mdpi.com/2073-4352/11/3/224

Similar Items

Identification, Expression and Evolution of Short-Chain Dehydrogenases/Reductases in Nile Tilapia (<i>Oreochromis Niloticus</i>)
by: Shuai Zhang, et al.
Published: (2021-04-01)

The Significance of the Sulfatase Pathway for Local Estrogen Formation in Endometrial Cancer
by: Maša Sinreih, et al.
Published: (2017-06-01)

Substrate specificities of peroxisomal members of short-chain alcohol dehydrogenase superfamily: expression and characterization of dehydrogenase part of Candida tropicalismultifunctional enzyme
by: Yong-Mei Qin, et al.
Published: (2000-01-01)

16th Carbonyl Metabolism Meeting: from enzymology to genomics
by: Maser Edmund
Published: (2012-12-01)

The Aldehyde Dehydrogenase Gene Superfamily Resource Center
by: Black William, et al.
Published: (2009-12-01)

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates
by: A Daniel Bird, et al.
Published: (2017-09-01)

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
by: Heidi L. Doden, et al.
Published: (2021-02-01)

11β-hydroxysteroid dehydrogenase types 1 and 2 in postnatal development of rat testis: gene expression, localization and regulation by luteinizing hormone and androgens
by: Hong-Yu Zhou, et al.
Published: (2014-12-01)

Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
by: Yiyan Wang, et al.
Published: (2019-07-01)

Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase: A Review
by: Galia Zamaratskaia, et al.
Published: (2013-09-01)

Piper sarmentosum Effects on 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme in Serum and Bone in Rat Model of Glucocorticoid-Induced Osteoporosis
by: Siti Fadziyah Mohamad Asri, et al.
Published: (2016-11-01)

Piper sarmentosum effects on 11β-hydroxysteroid dehydrogenase type 1 enzyme in serum and bone in rat model of glucocorticoid-induced osteoporosis
by: Asri, S.F.M, et al.
Published: (2016)

Relationship between carcass weight, adipose tissue androstenone level and expression of the hepatic 3β-hydroxysteroid dehydrogenase in entire commercial pigs
by: S.I. Nicolau-Solano, et al.
Published: (2007-01-01)

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases
by: Roger T. Engeli, et al.
Published: (2017-09-01)

Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells
by: Matthew J Randall, et al.
Published: (2015-01-01)

Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
by: Markey KA, et al.
Published: (2016-04-01)

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases
by: Teresa Kaserer, et al.
Published: (2015-12-01)

5-Bis-(2,6-difluoro-benzylidene) Cyclopentanone Acts as a Selective 11β-Hydroxysteroid Dehydrogenase one Inhibitor to Treat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
by: Hongguo Guan, et al.
Published: (2021-04-01)

Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population
by: Paulina Hejduk, et al.
Published: (2015-11-01)

Taxifolin is a rat and human 11β-hydroxysteroid dehydrogenase 1 inhibitor as a possible drug to treat the metabolic syndrome
by: Jianliang Sun, et al.
Published: (2018-10-01)

17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer
by: Chiaki Hashimoto, et al.
Published: (2018-04-01)

Regulation of Expression and Physiological Function of Type Ⅵ 3β-Hydroxysteroid Dehydrogenase Isozyme Hsd3b6
by: Yarimizu, Daisuke
Published: (2019)

Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes
by: Inder Warrick J, et al.
Published: (2012-12-01)

The Effects of Piper Sarmentosum Water Extract on the Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 in the Bones with Excessive Glucocorticoids
by: Elvy Suhana Mohd Ramli, et al.
Published: (2012-03-01)

High Throughput Screening Platform for a FAD-Dependent L-Sorbose Dehydrogenase
by: Xiaoyu Shan, et al.
Published: (2020-03-01)

17β-Hydroxysteroid dehydrogenases/17-ketosteroid reductases (17HSD/KSRs) in prostate cancer:the role of 17HSD/KSR types 2, 5, and 7 in steroid hormone action and loss of heterozygosity at chromosome region 16q
by: Härkönen, P. (Päivi)
Published: (2005)

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin
by: Beom Jun Kim, et al.
Published: (2021-05-01)

Structural and Mechanistic Studies on α-Amino β-Carboxymuconate ε-Semialdehyde Decarboxylase and α-Aminomuconate ε-Semialdehyde Dehydrogenase
by: Huo, Lu
Published: (2014)

The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3
by: Yating Cheng, et al.
Published: (2020-05-01)

11 B [i.e. Eleven beta] - Hydroxysteroid NADP Oxidoreductase in mouse foetal tissues
by: Michaud, Nicole Jocelyne
Published: (2010)

Identification of Important Chemical Features of 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors: Application of Ligand Based Virtual Screening and Density Functional Theory
by: Keun Woo Lee, et al.
Published: (2012-04-01)

Influence of Indomethacin on Steroid Metabolism: Endocrine Disruption and Confounding Effects in Urinary Steroid Profiling of Anti-Doping Analyses
by: Anna Stoll, et al.
Published: (2020-11-01)

BIOLOGICAL ROLE OF ALDO-KETO REDUCTASES IN RETINOIC ACID BIOSYNTHESIS AND SIGNALING
by: F. Xavier eRuiz, et al.
Published: (2012-04-01)

Babesia microti Aldo-keto Reductase-Like Protein Involved in Antioxidant and Anti-parasite Response
by: Qiang Huang, et al.
Published: (2017-10-01)

The Role of AKR1B10 in Physiology and Pathophysiology
by: Satoshi Endo, et al.
Published: (2021-05-01)

Synthesis of 5&#945;-Androstane-17-spiro-&#948;-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17&#946;-Hydroxysteroid Dehydrogenases
by: Donald Poirier, et al.
Published: (2013-01-01)

Studies on Structure-Function Relationship and Conversion of Coenzyme Requirement in Bacterial α-Keto Acid Reductases Responsible for Metabolism of Acidic Polysaccharides
by: Takase, Ryuichi
Published: (2015)

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells
by: Anthony E. Michael, et al.
Published: (2019-10-01)

Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 as Potential Drugs for Type 2 Diabetes Mellitus—A Systematic Review of Clinical and In Vivo Preclinical Studies
by: Cristiana Almeida, et al.
Published: (2021-01-01)

Gene mining-based identification of aldo–keto reductases for highly stereoselective reduction of bulky ketones
by: Chen Liang, et al.
Published: (2018-07-01)