Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy

Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy

Abstract Background In spite of disrupted repolarization of diabetic heart, some studies report less tendency of diabetic heart to develop ventricular arrhythmias suggesting effective compensatory mechanism. We hypothesized that myocardial alterations in HCN2 and HCN4 channels occur under hyperglyca...

Full description

Bibliographic Details
Main Authors: Katarina Hadova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Zuzana Kmecova, Peter Krenek, Jan Klimas
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Cardiovascular Disorders
Subjects:
HCN channels
Arrhythmias
Diabetic cardiomyopathy
Heart
Electrophysiology
Rat
Online Access:https://doi.org/10.1186/s12872-021-01929-3

Internet

https://doi.org/10.1186/s12872-021-01929-3

Similar Items