Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy
Abstract Background In spite of disrupted repolarization of diabetic heart, some studies report less tendency of diabetic heart to develop ventricular arrhythmias suggesting effective compensatory mechanism. We hypothesized that myocardial alterations in HCN2 and HCN4 channels occur under hyperglyca...
Main Authors: | Katarina Hadova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Zuzana Kmecova, Peter Krenek, Jan Klimas |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-03-01
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Series: | BMC Cardiovascular Disorders |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12872-021-01929-3 |
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