mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics

mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics

The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characteristics. Several crosstalk mechanisms have been de...

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Bibliographic Details
Main Authors: Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T. Saunders, Sunil Kumar, Robert N. Nishimura, Joseph Gera
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
mTORC2
YAP
Signal transduction
Phosphorylation
Glioblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000609

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