Clinical observation of cyclosporine eye drops with artificial tears for dry eyes

• Main Authors: Xue-Bing Yang, Feng-Zhi Cao
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2016-05-01
• Series: Guoji Yanke Zazhi
• Subjects: cyclosporine eye drops; artificial tears; dry eyes
• Online Access: http://ies.ijo.cn/cn_publish/2016/5/201605033.pdf

AIM:To explore the therapeutic effect of cyclosporine eye drops combined with artificial tears for dry eyes. <p>METHODS:One hundred and two patients(204 eyes)with dry eye as the research objects were collected from January 2015 to November 2015 and randomly divided into 3 groups:control group, subgroup A, subgroup B, 34 patients(68 eyes)in each group. The control group did not do special treatment. Subgroup A was treated with artificial tears eye drops 3 times per day and subgroup B with cyclosporine eye drop first, 15min later with artificial tears, 3 times per day. All patients were treated for 8wk. Tear ferning test(TFT), corneal fluorescein staining(FL), Schirmer I test(SIt), breakup time of tear film(BUT)and conjunctive impression cytology(CIC)in each group were observed and compared. <p>RESULTS:(1)At 4wk after treatment, fern fractional crystallization grade of subgroup B was better than those of subgroup A and control group(<i>χ</i>²=16.345,<i>P</i>=0.003); at 8wk after treatment, fern fractional crystallization grade of subgroup B was better than those of subgroup A and control group(<i>P</i><0.05).(2)The FL of control group at 8wk was worse compared with before treatment(<i>t</i>=-4.500,<i>P</i>=0.003); the FL of subgroup A and subgroup B became lighter and the scores decreased compared with before treatment(<i>P</i><0.05); at 4 and 8wk after treatment, the FL scores of subgroup B were lower than those of subgroup A(<i>t</i>=3.553, <i>P</i>=0.006; <i>t</i>=4.523, <i>P</i>=0.001).(3)Compared with control group, the BUT of subgroup B at 4 and 8wk prolonged(<i>P</i><0.05); the BUT of subgroup B had no difference with subgroup A(<i>P</i>>0.05).(4)At 8wk after treatment, conjunctival impression cytology of subgroup B was better than those of the control group and subgroup A(<i>P</i><0.05).(5)At 4wk after treatment, SIt of subgroup B increased, compared with subgroup A and the control group(<i>χ</i>²=6.384, <i>P</i>=0.012); at 8wk after treatment, SIt of subgroup A and B were better than those before the treatment, SIt of the B subgroup was better than that of subgroup A(all <i>P</i><0.05).<p>CONCLUSION:Cyclosporin eye drops combined with artificial tears can improve micro environment of the tear, increase the amount of tear secretion, extend BUT and enhance the stability of the tear film.