Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis
Multiple myeloma is the most common plasma cell dyscrasia and causes 2% of all cancer deaths in Western countries. Ovarian carcinosarcomas are very rare gynecological malignancies and account for only 1–2% of all ovarian tumors. In this case, we report a 67-year-old woman with known relapsed ovarian...
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doaj-b020f447bf2b4ab6ac50b651b3007d992020-11-25T01:17:18ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/30296503029650Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and DiagnosisRobert Stuver0Alec Petersen1Thomas A. Guerrero-Garcia2Ursula Matulonis3Paul Richardson4Prabhsimranjot Singh5Beth Israel Deaconess Medical Center, Department of Internal Medicine, 330 Brookline Avenue, Boston, MA 02215, USABrigham and Women’s Hospital, Department of Internal Medicine, 45 Francis Street, Boston, MA 02115, USADana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USADana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USADana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USADana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USAMultiple myeloma is the most common plasma cell dyscrasia and causes 2% of all cancer deaths in Western countries. Ovarian carcinosarcomas are very rare gynecological malignancies and account for only 1–2% of all ovarian tumors. In this case, we report a 67-year-old woman with known relapsed ovarian carcinosarcoma who presented with headache and neck pain. She was found to have new lytic lesions in the cranial and thoracic regions. While these lesions were assumed to be metastases, a diligent approach detected an M-spike on serum protein electrophoresis and a monoclonal gammopathy with immunoglobulin G lambda monoclonal immunoglobulin on immunofixation. A bone marrow biopsy confirmed the diagnosis of multiple myeloma. To our knowledge, this is the first ever reported case of concomitant multiple myeloma and ovarian carcinosarcoma. Our case highlights the utmost importance of a systematic approach to lytic lesions and emphasizes the need to consider secondary malignancies in the evaluation of possible metastases. We used the International Myeloma Working Group guidelines for screening and diagnosing multiple myeloma, and we provide a thorough review of this updated approach.http://dx.doi.org/10.1155/2018/3029650 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robert Stuver Alec Petersen Thomas A. Guerrero-Garcia Ursula Matulonis Paul Richardson Prabhsimranjot Singh |
spellingShingle |
Robert Stuver Alec Petersen Thomas A. Guerrero-Garcia Ursula Matulonis Paul Richardson Prabhsimranjot Singh Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis Case Reports in Hematology |
author_facet |
Robert Stuver Alec Petersen Thomas A. Guerrero-Garcia Ursula Matulonis Paul Richardson Prabhsimranjot Singh |
author_sort |
Robert Stuver |
title |
Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis |
title_short |
Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis |
title_full |
Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis |
title_fullStr |
Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis |
title_full_unstemmed |
Multiple Myeloma Masquerading as Ovarian Carcinosarcoma Metastases: A Case Report and Review of the Approach to Multiple Myeloma Screening and Diagnosis |
title_sort |
multiple myeloma masquerading as ovarian carcinosarcoma metastases: a case report and review of the approach to multiple myeloma screening and diagnosis |
publisher |
Hindawi Limited |
series |
Case Reports in Hematology |
issn |
2090-6560 2090-6579 |
publishDate |
2018-01-01 |
description |
Multiple myeloma is the most common plasma cell dyscrasia and causes 2% of all cancer deaths in Western countries. Ovarian carcinosarcomas are very rare gynecological malignancies and account for only 1–2% of all ovarian tumors. In this case, we report a 67-year-old woman with known relapsed ovarian carcinosarcoma who presented with headache and neck pain. She was found to have new lytic lesions in the cranial and thoracic regions. While these lesions were assumed to be metastases, a diligent approach detected an M-spike on serum protein electrophoresis and a monoclonal gammopathy with immunoglobulin G lambda monoclonal immunoglobulin on immunofixation. A bone marrow biopsy confirmed the diagnosis of multiple myeloma. To our knowledge, this is the first ever reported case of concomitant multiple myeloma and ovarian carcinosarcoma. Our case highlights the utmost importance of a systematic approach to lytic lesions and emphasizes the need to consider secondary malignancies in the evaluation of possible metastases. We used the International Myeloma Working Group guidelines for screening and diagnosing multiple myeloma, and we provide a thorough review of this updated approach. |
url |
http://dx.doi.org/10.1155/2018/3029650 |
work_keys_str_mv |
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