Cancer Stem Cells and Epithelial Ovarian Cancer
The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties. Cancer stem cells (CSCs), or tumour-ini...
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2010-01-01
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Series: | Journal of Oncology |
Online Access: | http://dx.doi.org/10.1155/2010/105269 |
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doaj-b029e7276dc04946bed67f41e0da3f882020-11-24T21:34:00ZengHindawi LimitedJournal of Oncology1687-84501687-84692010-01-01201010.1155/2010/105269105269Cancer Stem Cells and Epithelial Ovarian CancerSheetal Dyall0Simon A. Gayther1Dimitra Dafou2Gynaecological Cancer Research Laboratory, EGA UCL Institute for Women's Health, London WC1E 6DD, UKGynaecological Cancer Research Laboratory, EGA UCL Institute for Women's Health, London WC1E 6DD, UKGynaecological Cancer Research Laboratory, EGA UCL Institute for Women's Health, London WC1E 6DD, UKThe cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells specifically, eradicating the cancer completely. There have been several reports describing the isolation of putative cancer stem cell populations in several cancers; however, no defined set of markers has been identified that conclusively characterises “stem-like” cancer cells. This paper highlights the current experimental approaches that have been used in the field and discusses their limitations, with specific emphasis on the identification and characterisation of the CSC population in epithelial ovarian cancer.http://dx.doi.org/10.1155/2010/105269 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sheetal Dyall Simon A. Gayther Dimitra Dafou |
spellingShingle |
Sheetal Dyall Simon A. Gayther Dimitra Dafou Cancer Stem Cells and Epithelial Ovarian Cancer Journal of Oncology |
author_facet |
Sheetal Dyall Simon A. Gayther Dimitra Dafou |
author_sort |
Sheetal Dyall |
title |
Cancer Stem Cells and Epithelial Ovarian Cancer |
title_short |
Cancer Stem Cells and Epithelial Ovarian Cancer |
title_full |
Cancer Stem Cells and Epithelial Ovarian Cancer |
title_fullStr |
Cancer Stem Cells and Epithelial Ovarian Cancer |
title_full_unstemmed |
Cancer Stem Cells and Epithelial Ovarian Cancer |
title_sort |
cancer stem cells and epithelial ovarian cancer |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2010-01-01 |
description |
The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells specifically, eradicating the cancer completely. There have been several reports describing the isolation of putative cancer stem cell populations in several cancers; however, no defined set of markers has been identified that conclusively characterises “stem-like” cancer cells. This paper highlights the current experimental approaches that have been used in the field and discusses their limitations, with specific emphasis on the identification and characterisation of the CSC population in epithelial ovarian cancer. |
url |
http://dx.doi.org/10.1155/2010/105269 |
work_keys_str_mv |
AT sheetaldyall cancerstemcellsandepithelialovariancancer AT simonagayther cancerstemcellsandepithelialovariancancer AT dimitradafou cancerstemcellsandepithelialovariancancer |
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1725950891473764352 |