Role of Leptin in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence has bee...
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doaj-b02ec65be262458b86daa551c1d413312021-07-23T13:31:36ZengMDPI AGBiomedicines2227-90592021-06-01976276210.3390/biomedicines9070762Role of Leptin in Non-Alcoholic Fatty Liver DiseaseCarlos Jiménez-Cortegana0Alba García-Galey1Malika Tami2Pilar del Pino3Isabel Carmona4Soledad López5Gonzalo Alba6Víctor Sánchez-Margalet7Department of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainUnit of Digestive Diseases, Virgen Macarena University Hospital, 41073 Seville, SpainUnit of Digestive Diseases, Virgen Macarena University Hospital, 41073 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Virgen Macarena University Hospital, University of Seville, 41073 Seville, SpainNon-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence has been rapidly driven by increased physical inactivity, in addition to excessive calorie intake compared to energy expenditure, affecting both adults and children. The increase in the number of cases, together with the higher morbimortality that this disease entails with respect to the general population, makes NAFLD a serious public health problem. Closely related to the development of this disease, there is a hormone derived from adipocytes, leptin, which is involved in energy homeostasis and lipid metabolism. Numerous studies have verified the relationship between persistent hyperleptinemia and the development of steatosis, fibrinogenesis and liver carcinogenesis. Therefore, further studies of the role of leptin in the NAFLD spectrum could represent an advance in the management of this set of diseases.https://www.mdpi.com/2227-9059/9/7/762fatty liversteatohepatitisobesitymetabolic syndromeleptin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Jiménez-Cortegana Alba García-Galey Malika Tami Pilar del Pino Isabel Carmona Soledad López Gonzalo Alba Víctor Sánchez-Margalet |
spellingShingle |
Carlos Jiménez-Cortegana Alba García-Galey Malika Tami Pilar del Pino Isabel Carmona Soledad López Gonzalo Alba Víctor Sánchez-Margalet Role of Leptin in Non-Alcoholic Fatty Liver Disease Biomedicines fatty liver steatohepatitis obesity metabolic syndrome leptin |
author_facet |
Carlos Jiménez-Cortegana Alba García-Galey Malika Tami Pilar del Pino Isabel Carmona Soledad López Gonzalo Alba Víctor Sánchez-Margalet |
author_sort |
Carlos Jiménez-Cortegana |
title |
Role of Leptin in Non-Alcoholic Fatty Liver Disease |
title_short |
Role of Leptin in Non-Alcoholic Fatty Liver Disease |
title_full |
Role of Leptin in Non-Alcoholic Fatty Liver Disease |
title_fullStr |
Role of Leptin in Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed |
Role of Leptin in Non-Alcoholic Fatty Liver Disease |
title_sort |
role of leptin in non-alcoholic fatty liver disease |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-06-01 |
description |
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence has been rapidly driven by increased physical inactivity, in addition to excessive calorie intake compared to energy expenditure, affecting both adults and children. The increase in the number of cases, together with the higher morbimortality that this disease entails with respect to the general population, makes NAFLD a serious public health problem. Closely related to the development of this disease, there is a hormone derived from adipocytes, leptin, which is involved in energy homeostasis and lipid metabolism. Numerous studies have verified the relationship between persistent hyperleptinemia and the development of steatosis, fibrinogenesis and liver carcinogenesis. Therefore, further studies of the role of leptin in the NAFLD spectrum could represent an advance in the management of this set of diseases. |
topic |
fatty liver steatohepatitis obesity metabolic syndrome leptin |
url |
https://www.mdpi.com/2227-9059/9/7/762 |
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