Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors
Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations. NRP1 functions as a co-receptor, binding numerous ligands, such as SEMA 3 or VEGF and, by doing so, reinforcing their signaling pathways a...
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doaj-b02fe284b9a446c0a498c64f276cfc472021-07-01T14:22:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.665634665634Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain TumorsManon Douyère0Pascal Chastagner1Pascal Chastagner2Cédric Boura3Université de Lorraine, CNRS, CRAN, Nancy, FranceUniversité de Lorraine, CNRS, CRAN, Nancy, FranceService d’Onco-Hématologie Pédiatrique, CHRU-Nancy, Nancy, FranceUniversité de Lorraine, CNRS, CRAN, Nancy, FranceNeuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations. NRP1 functions as a co-receptor, binding numerous ligands, such as SEMA 3 or VEGF and, by doing so, reinforcing their signaling pathways and can also interface with the cytoplasmic protein synectin. NRP1 is expressed in many cancers, such as brain cancers, and is associated with poor prognosis. The challenge today for patients with pediatric brain tumors is to improve their survival rate while minimizing the toxicity of current treatments. The aim of this review is to highlight the involvement of NRP1 in pediatric brain cancers, focusing essentially on the roles of NRP1 in cancer stem cells and in the regulation of the immune system. For this purpose, recent literature and tumor databases were analyzed to show correlations between NRP1 and CD15 (a stem cancer cells marker), and between NRP1 and PDL1, for various pediatric brain tumors, such as high- and low-grade gliomas, medulloblastomas, and ependymomas. Finally, this review suggests a relevant role for NRP1 in pediatric brain tumors progression and identifies it as a potential diagnostic or therapeutic target to improve survival and life quality of these young patients.https://www.frontiersin.org/articles/10.3389/fonc.2021.665634/fullneuropilinspediatric brain tumorcancer stem cellsimmune systemgliomamedulloblastoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manon Douyère Pascal Chastagner Pascal Chastagner Cédric Boura |
spellingShingle |
Manon Douyère Pascal Chastagner Pascal Chastagner Cédric Boura Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors Frontiers in Oncology neuropilins pediatric brain tumor cancer stem cells immune system glioma medulloblastoma |
author_facet |
Manon Douyère Pascal Chastagner Pascal Chastagner Cédric Boura |
author_sort |
Manon Douyère |
title |
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors |
title_short |
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors |
title_full |
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors |
title_fullStr |
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors |
title_full_unstemmed |
Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors |
title_sort |
neuropilin-1: a key protein to consider in the progression of pediatric brain tumors |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-07-01 |
description |
Neuropilins are transmembrane glycoproteins that play important roles in cardiovascular and neuronal development, as well as in immunological system regulations. NRP1 functions as a co-receptor, binding numerous ligands, such as SEMA 3 or VEGF and, by doing so, reinforcing their signaling pathways and can also interface with the cytoplasmic protein synectin. NRP1 is expressed in many cancers, such as brain cancers, and is associated with poor prognosis. The challenge today for patients with pediatric brain tumors is to improve their survival rate while minimizing the toxicity of current treatments. The aim of this review is to highlight the involvement of NRP1 in pediatric brain cancers, focusing essentially on the roles of NRP1 in cancer stem cells and in the regulation of the immune system. For this purpose, recent literature and tumor databases were analyzed to show correlations between NRP1 and CD15 (a stem cancer cells marker), and between NRP1 and PDL1, for various pediatric brain tumors, such as high- and low-grade gliomas, medulloblastomas, and ependymomas. Finally, this review suggests a relevant role for NRP1 in pediatric brain tumors progression and identifies it as a potential diagnostic or therapeutic target to improve survival and life quality of these young patients. |
topic |
neuropilins pediatric brain tumor cancer stem cells immune system glioma medulloblastoma |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.665634/full |
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