ω-Carboxyl variants of 7-ketocholesteryl esters are ligands for β2-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages

ω-Carboxyl variants of 7-ketocholesteryl esters are ligands for β2-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages

β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL, Abs) present in patients with antiphospholipid syndrome. We recently reported that β2-GPI specifically binds to oxidized LDL (oxLDL) and that the β2-GPI's major ligand, oxLig-1 is 7-ketocholesteryl-9-carboxynonan...

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Bibliographic Details
Main Authors: Qingping Liu, Kazuko Kobayashi, Jun-ichi Furukawa, Junko Inagaki, Nobuo Sakairi, Akimasa Iwado, Tatsuji Yasuda, Takao Koike, Dennis R. Voelker, Eiji Matsuura
Format: Article
Language:English
Published: Elsevier 2002-09-01
Series:Journal of Lipid Research
Subjects:
antiphospholipid syndrome
atherosclerosis
autoantibody
β2-glycoprotein I
oxidized LDL
ω-oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328133

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http://www.sciencedirect.com/science/article/pii/S0022227520328133

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