Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial
Abstract Background The multicentre randomised controlled PEPaNIC trial showed that withholding parenteral nutrition (PN) during the first week of critical illness in children was clinically superior to providing early PN. This study describes the cost-effectiveness of this new nutritional strategy....
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doaj-b040f3cfccc546c98b1fce3e0f023d842020-11-24T22:00:51ZengBMCCritical Care1364-85352018-01-012211910.1186/s13054-017-1936-2Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trialEsther van Puffelen0Suzanne Polinder1Ilse Vanhorebeek2Pieter Jozef Wouters3Niek Bossche4Guido Peers5Sören Verstraete6Koen Felix Maria Joosten7Greet Van den Berghe8Sascha Cornelis Antonius Theodorus Verbruggen9Dieter Mesotten10Intensive Care Unit, Department of Paediatrics and Paediatric Surgery, Erasmus Medical Centre, Sophia Children’s HospitalDepartment of Public Health, Erasmus Medical CentreClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, University Hospitals LeuvenClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, University Hospitals LeuvenDepartment of Control and Compliance, Erasmus Medical CentreDepartment Medical Administration, University Hospitals LeuvenClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, University Hospitals LeuvenIntensive Care Unit, Department of Paediatrics and Paediatric Surgery, Erasmus Medical Centre, Sophia Children’s HospitalClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, University Hospitals LeuvenIntensive Care Unit, Department of Paediatrics and Paediatric Surgery, Erasmus Medical Centre, Sophia Children’s HospitalClinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, University Hospitals LeuvenAbstract Background The multicentre randomised controlled PEPaNIC trial showed that withholding parenteral nutrition (PN) during the first week of critical illness in children was clinically superior to providing early PN. This study describes the cost-effectiveness of this new nutritional strategy. Methods Direct medical costs were calculated with use of a micro-costing approach. We compared the costs of late versus early initiation of PN (n = 673 versus n = 670 patients) in the Belgian and Dutch study populations from a hospital perspective, using Student’s t test with bootstrapping. Main cost drivers were identified and the impact of new infections on the total costs was assessed. Results Mean direct medical costs for patients receiving late PN (€26.680, IQR €10.090–28.830 per patient) were 21% lower (-€7.180, p = 0.007) than for patients receiving early PN (€33.860, IQR €11.080–34.720). Since late PN was more effective and less costly, this strategy was superior to early PN. The lower costs for PN only contributed 2.1% to the total cost reduction. The main cost driver was intensive care hospitalisation costs (-€4.120, p = 0.003). The patients who acquired a new infection (14%) were responsible for 41% of the total costs. Sensitivity analyses confirmed consistency across both healthcare systems. Conclusions Late initiation of PN decreased the direct medical costs for hospitalisation in critically ill children, beyond the expected lower costs for withholding PN. Avoiding new infections by late initiation of PN yielded a large cost reduction. Hence, late initiation of PN was superior to early initiation of PN largely via its effect on new infections. Trial registration ClinicalTrials.gov, NCT01536275 . Registered on 16 February 2012.http://link.springer.com/article/10.1186/s13054-017-1936-2Parenteral nutritionCost-effectivenessHealth economicsCostsIntensive care |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esther van Puffelen Suzanne Polinder Ilse Vanhorebeek Pieter Jozef Wouters Niek Bossche Guido Peers Sören Verstraete Koen Felix Maria Joosten Greet Van den Berghe Sascha Cornelis Antonius Theodorus Verbruggen Dieter Mesotten |
spellingShingle |
Esther van Puffelen Suzanne Polinder Ilse Vanhorebeek Pieter Jozef Wouters Niek Bossche Guido Peers Sören Verstraete Koen Felix Maria Joosten Greet Van den Berghe Sascha Cornelis Antonius Theodorus Verbruggen Dieter Mesotten Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial Critical Care Parenteral nutrition Cost-effectiveness Health economics Costs Intensive care |
author_facet |
Esther van Puffelen Suzanne Polinder Ilse Vanhorebeek Pieter Jozef Wouters Niek Bossche Guido Peers Sören Verstraete Koen Felix Maria Joosten Greet Van den Berghe Sascha Cornelis Antonius Theodorus Verbruggen Dieter Mesotten |
author_sort |
Esther van Puffelen |
title |
Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial |
title_short |
Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial |
title_full |
Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial |
title_fullStr |
Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial |
title_full_unstemmed |
Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial |
title_sort |
cost-effectiveness study of early versus late parenteral nutrition in critically ill children (pepanic): preplanned secondary analysis of a multicentre randomised controlled trial |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2018-01-01 |
description |
Abstract Background The multicentre randomised controlled PEPaNIC trial showed that withholding parenteral nutrition (PN) during the first week of critical illness in children was clinically superior to providing early PN. This study describes the cost-effectiveness of this new nutritional strategy. Methods Direct medical costs were calculated with use of a micro-costing approach. We compared the costs of late versus early initiation of PN (n = 673 versus n = 670 patients) in the Belgian and Dutch study populations from a hospital perspective, using Student’s t test with bootstrapping. Main cost drivers were identified and the impact of new infections on the total costs was assessed. Results Mean direct medical costs for patients receiving late PN (€26.680, IQR €10.090–28.830 per patient) were 21% lower (-€7.180, p = 0.007) than for patients receiving early PN (€33.860, IQR €11.080–34.720). Since late PN was more effective and less costly, this strategy was superior to early PN. The lower costs for PN only contributed 2.1% to the total cost reduction. The main cost driver was intensive care hospitalisation costs (-€4.120, p = 0.003). The patients who acquired a new infection (14%) were responsible for 41% of the total costs. Sensitivity analyses confirmed consistency across both healthcare systems. Conclusions Late initiation of PN decreased the direct medical costs for hospitalisation in critically ill children, beyond the expected lower costs for withholding PN. Avoiding new infections by late initiation of PN yielded a large cost reduction. Hence, late initiation of PN was superior to early initiation of PN largely via its effect on new infections. Trial registration ClinicalTrials.gov, NCT01536275 . Registered on 16 February 2012. |
topic |
Parenteral nutrition Cost-effectiveness Health economics Costs Intensive care |
url |
http://link.springer.com/article/10.1186/s13054-017-1936-2 |
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