Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity

Berberine Suppresses Colonic Inflammation in Dextran Sulfate Sodium–Induced Murine Colitis Through Inhibition of Cytosolic Phospholipase A2 Activity

Ulcerative colitis (UC) causes chronic inflammation and damage to the colonic mucosal layer. Recent studies have reported significant changes in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) in UC patients and oral administration of PC has considerable therapeutic effects against UC, su...

Full description

Bibliographic Details
Main Authors: Lixiang Zhai, Tao Huang, Hai-tao Xiao, Pei-gen Wu, Cheng-yuan Lin, Zi-wan Ning, Ling Zhao, Hiu Yee Anna Kwan, Xian-jing Hu, Hoi Leong Xavier Wong, Xian-qian Li, Zhao-xiang Bian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
macrophage
phospholipase A2
lysophosphatidylcholine
berberine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.576496/full

Similar Items

Similar Items