Sublingual immunization with a live attenuated influenza a virus lacking the nonstructural protein 1 induces broad protective immunity in mice.
The nonstructural protein 1 (NS1) of influenza A virus (IAV) enables the virus to disarm the host cell type 1 IFN defense system. Mutation or deletion of the NS1 gene leads to attenuation of the virus and enhances host antiviral response making such live-attenuated influenza viruses attractive vacci...
Main Authors: | Hae-Jung Park, Boris Ferko, Young-Ho Byun, Joo-Hye Song, Gye-Yeong Han, Elisabeth Roethl, Andrej Egorov, Thomas Muster, Baiklin Seong, Mi-Na Kweon, Manki Song, Cecil Czerkinsky, Huan H Nguyen |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3384633?pdf=render |
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