Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11008 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Qiao Fan Virginie J. M. Verhoeven Robert Wojciechowski Veluchamy A. Barathi Pirro G. Hysi Jeremy A. Guggenheim René Höhn Veronique Vitart Anthony P. Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W. Hewitt Xiaobo Guo Johanna Mazur Jenifer E. Huffman Katie M. Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F. Wilson Peter K. Joshi George McMahon Beate St Pourcain David M. Evans Claire L. Simpson Tae-Hwi Schwantes-An Robert P. Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppälä Tanja Zeller Thomas Meitinger Janina S. Ried Christian Gieger Laura Portas Elisabeth M. van Leeuwen Najaf Amin André G. Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R. Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M. Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E. H. Ho Wan’e Lim Roger W. Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N. Luben Paul J. Foster Barbara E. K. Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L. Young Mingguang He Olavi Pärssinen Cornelia M. van Duijn Jie Jin Wang Cathy Williams Jost B. Jonas Yik-Ying Teo David A. Mackey Konrad Oexle Nagahisa Yoshimura Andrew D. Paterson Norbert Pfeiffer Tien-Yin Wong Paul N. Baird Dwight Stambolian Joan E. Bailey Wilson Ching-Yu Cheng Christopher J. Hammond Caroline C. W. Klaver Seang-Mei Saw Consortium for Refractive Error and Myopia (CREAM) |
| spellingShingle |
Qiao Fan Virginie J. M. Verhoeven Robert Wojciechowski Veluchamy A. Barathi Pirro G. Hysi Jeremy A. Guggenheim René Höhn Veronique Vitart Anthony P. Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W. Hewitt Xiaobo Guo Johanna Mazur Jenifer E. Huffman Katie M. Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F. Wilson Peter K. Joshi George McMahon Beate St Pourcain David M. Evans Claire L. Simpson Tae-Hwi Schwantes-An Robert P. Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppälä Tanja Zeller Thomas Meitinger Janina S. Ried Christian Gieger Laura Portas Elisabeth M. van Leeuwen Najaf Amin André G. Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R. Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M. Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E. H. Ho Wan’e Lim Roger W. Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N. Luben Paul J. Foster Barbara E. K. Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L. Young Mingguang He Olavi Pärssinen Cornelia M. van Duijn Jie Jin Wang Cathy Williams Jost B. Jonas Yik-Ying Teo David A. Mackey Konrad Oexle Nagahisa Yoshimura Andrew D. Paterson Norbert Pfeiffer Tien-Yin Wong Paul N. Baird Dwight Stambolian Joan E. Bailey Wilson Ching-Yu Cheng Christopher J. Hammond Caroline C. W. Klaver Seang-Mei Saw Consortium for Refractive Error and Myopia (CREAM) Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error Nature Communications |
| author_facet |
Qiao Fan Virginie J. M. Verhoeven Robert Wojciechowski Veluchamy A. Barathi Pirro G. Hysi Jeremy A. Guggenheim René Höhn Veronique Vitart Anthony P. Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W. Hewitt Xiaobo Guo Johanna Mazur Jenifer E. Huffman Katie M. Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F. Wilson Peter K. Joshi George McMahon Beate St Pourcain David M. Evans Claire L. Simpson Tae-Hwi Schwantes-An Robert P. Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppälä Tanja Zeller Thomas Meitinger Janina S. Ried Christian Gieger Laura Portas Elisabeth M. van Leeuwen Najaf Amin André G. Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R. Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M. Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E. H. Ho Wan’e Lim Roger W. Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N. Luben Paul J. Foster Barbara E. K. Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L. Young Mingguang He Olavi Pärssinen Cornelia M. van Duijn Jie Jin Wang Cathy Williams Jost B. Jonas Yik-Ying Teo David A. Mackey Konrad Oexle Nagahisa Yoshimura Andrew D. Paterson Norbert Pfeiffer Tien-Yin Wong Paul N. Baird Dwight Stambolian Joan E. Bailey Wilson Ching-Yu Cheng Christopher J. Hammond Caroline C. W. Klaver Seang-Mei Saw Consortium for Refractive Error and Myopia (CREAM) |
| author_sort |
Qiao Fan |
| title |
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| title_short |
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| title_full |
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| title_fullStr |
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| title_full_unstemmed |
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| title_sort |
meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-04-01 |
| description |
This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors. |
| url |
https://doi.org/10.1038/ncomms11008 |
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doaj-b0563139c510416e9a4da61510e1f5d42021-05-11T10:37:46ZengNature Publishing GroupNature Communications2041-17232016-04-017111210.1038/ncomms11008Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive errorQiao Fan0Virginie J. M. Verhoeven1Robert Wojciechowski2Veluchamy A. Barathi3Pirro G. Hysi4Jeremy A. Guggenheim5René Höhn6Veronique Vitart7Anthony P. Khawaja8Kenji Yamashiro9S Mohsen Hosseini10Terho Lehtimäki11Yi Lu12Toomas Haller13Jing Xie14Cécile Delcourt15Mario Pirastu16Juho Wedenoja17Puya Gharahkhani18Cristina Venturini19Masahiro Miyake20Alex W. Hewitt21Xiaobo Guo22Johanna Mazur23Jenifer E. Huffman24Katie M. Williams25Ozren Polasek26Harry Campbell27Igor Rudan28Zoran Vatavuk29James F. Wilson30Peter K. Joshi31George McMahon32Beate St Pourcain33David M. Evans34Claire L. Simpson35Tae-Hwi Schwantes-An36Robert P. Igo37Alireza Mirshahi38Audrey Cougnard-Gregoire39Céline Bellenguez40Maria Blettner41Olli Raitakari42Mika Kähönen43Ilkka Seppälä44Tanja Zeller45Thomas Meitinger46Janina S. Ried47Christian Gieger48Laura Portas49Elisabeth M. van Leeuwen50Najaf Amin51André G. Uitterlinden52Fernando Rivadeneira53Albert Hofman54Johannes R. Vingerling55Ya Xing Wang56Xu Wang57Eileen Tai-Hui Boh58M. Kamran Ikram59Charumathi Sabanayagam60Preeti Gupta61Vincent Tan62Lei Zhou63Candice E. H. Ho64Wan’e Lim65Roger W. Beuerman66Rosalynn Siantar67E-Shyong Tai68Eranga Vithana69Evelin Mihailov70Chiea-Chuen Khor71Caroline Hayward72Robert N. Luben73Paul J. Foster74Barbara E. K. Klein75Ronald Klein76Hoi-Suen Wong77Paul Mitchell78Andres Metspalu79Tin Aung80Terri L. Young81Mingguang He82Olavi Pärssinen83Cornelia M. van Duijn84Jie Jin Wang85Cathy Williams86Jost B. Jonas87Yik-Ying Teo88David A. Mackey89Konrad Oexle90Nagahisa Yoshimura91Andrew D. Paterson92Norbert Pfeiffer93Tien-Yin Wong94Paul N. Baird95Dwight Stambolian96Joan E. Bailey Wilson97Ching-Yu Cheng98Christopher J. Hammond99Caroline C. W. Klaver100Seang-Mei Saw101Consortium for Refractive Error and Myopia (CREAM)Singapore Eye Research Institute, Singapore National Eye CentreDepartment of Ophthalmology, Erasmus Medical CenterComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of HealthSingapore Eye Research Institute, Singapore National Eye CentreDepartment of Twin Research and Genetic Epidemiology, King’s College London School of MedicineSchool of Optometry and Vision Sciences, Cardiff UniversityDepartment of Ophthalmology, University Medical Center MainzMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineProgram in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of TorontoDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of TampereStatistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, HerstonEstonian Genome Center, University of TartuCentre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of MelbourneUniversité de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)Institute of Population Genetics, National Research CouncilDepartment of Public Health, University of HelsinkiStatistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, HerstonDepartment of Twin Research and Genetic Epidemiology, King’s College London School of MedicineDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineCentre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of MelbourneDepartment of Statistical Science, School of Mathematics and Computational Science, Sun Yat-Sen UniversityInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center MainzMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghDepartment of Twin Research and Genetic Epidemiology, King’s College London School of MedicineFaculty of Medicine, University of SplitUsher Institute for Population Health Sciences and Informatics, University of EdinburghUsher Institute for Population Health Sciences and Informatics, University of EdinburghDepartment of Ophthalmology, Sisters of Mercy University HospitalUsher Institute for Population Health Sciences and Informatics, University of EdinburghUsher Institute for Population Health Sciences and Informatics, University of EdinburghMRC Integrative Epidemiology Unit (IEU), University of BristolMRC Integrative Epidemiology Unit (IEU), University of BristolMRC Integrative Epidemiology Unit (IEU), University of BristolComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of HealthComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of HealthDepartment of Epidemiology and Biostatistics, Case Western Reserve UniversityDepartment of Ophthalmology, University Medical Center MainzUniversité de Bordeaux, ISPED (Institut de Santé Publique d'Épidémiologie et de Développement)Inserm, U1167Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center MainzResearch Centre of Applied and Preventive Medicine, University of TurkuDepartment of Clinical Physiology, Tampere University Hospital and School of Medicine, University of TampereDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of TampereClinic for General and Interventional Cardiology, University Heart Center HamburgInstitute of Human Genetics, Helmholtz Zentrum MünchenInstitute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental HealthInstitute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental HealthInstitute of Population Genetics, National Research CouncilDepartment of Epidemiology, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Epidemiology, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical CenterBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversitySaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemsSaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemsSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreDepartment of Ophthalmology, National University Health Systems, National University of SingaporeSingapore Eye Research Institute, Singapore National Eye CentreSingapore Eye Research Institute, Singapore National Eye CentreDuke-NUS Medical SchoolSingapore Eye Research Institute, Singapore National Eye CentreEstonian Genome Center, University of TartuSingapore Eye Research Institute, Singapore National Eye CentreMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of EdinburghDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical MedicineDivision of Genetics and Epidemiology, UCL Institute of OphthalmologyDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public HealthDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public HealthProgram in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of TorontoDepartment of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, AustraliaEstonian Genome Center, University of TartuSingapore Eye Research Institute, Singapore National Eye CentreDepartment of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of WisconsinState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen UniversityDepartment of Ophthalmology, Central Hospital of Central FinlandDepartment of Epidemiology, Erasmus Medical CenterDepartment of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales 2145, AustraliaSchool of Social and Community Medicine, University of BristolBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversitySaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemsMenzies Research Institute Tasmania, University of TasmaniaInstitute of Human Genetics, Klinikum rechts der Isar, Technische Universität MünchenDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of MedicineProgram in Genetics and Genome Biology, The Hospital for Sick Children and Institute for Medical Sciences, University of TorontoDepartment of Ophthalmology, University Medical Center MainzSingapore Eye Research Institute, Singapore National Eye CentreCentre for Eye Research Australia (CERA), Royal Victorian Eye and Ear Hospital, University of MelbourneDepartment of Ophthalmology, University of PennsylvaniaComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of HealthSingapore Eye Research Institute, Singapore National Eye CentreDepartment of Twin Research and Genetic Epidemiology, King’s College London School of MedicineDepartment of Ophthalmology, Erasmus Medical CenterSingapore Eye Research Institute, Singapore National Eye CentreThis report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors.https://doi.org/10.1038/ncomms11008 |