Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan
Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the...
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doaj-b0589cf8a1e74200931cdf89d0d77db52020-11-24T23:21:12ZengElsevierJournal of the Formosan Medical Association0929-66462006-01-01105322923410.1016/S0929-6646(09)60310-7Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in TaiwanRu-Cheng KuoChiao-Ying LinMark Yen-Ping KuoOverexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan. Methods: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Results: Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test). Conclusion: These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan.http://www.sciencedirect.com/science/article/pii/S0929664609603107c-Jun activationoral cancerprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ru-Cheng Kuo Chiao-Ying Lin Mark Yen-Ping Kuo |
spellingShingle |
Ru-Cheng Kuo Chiao-Ying Lin Mark Yen-Ping Kuo Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan Journal of the Formosan Medical Association c-Jun activation oral cancer prognosis |
author_facet |
Ru-Cheng Kuo Chiao-Ying Lin Mark Yen-Ping Kuo |
author_sort |
Ru-Cheng Kuo |
title |
Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan |
title_short |
Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan |
title_full |
Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan |
title_fullStr |
Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan |
title_full_unstemmed |
Prognostic Role of c-Jun Activation in Patients with Areca Quid Chewing-related Oral Squamous Cell Carcinomas in Taiwan |
title_sort |
prognostic role of c-jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in taiwan |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2006-01-01 |
description |
Overexpression or activation of c-Jun has been implicated in the pathogenesis of several types of cancer. Treatment of oral cells with areca nut extract in culture can increase c-Jun proto-oncogene mRNA levels. The purpose of this study was to investigate the possible role of c-Jun activation in the pathogenesis and prognosis of areca quid chewing-related oral cancer in Taiwan.
Methods: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections.
Results: Positive pc-Jun staining was observed in 42 of 70 (60%) cases of oral SCC. No significant correlation was found between pc-Jun expression and patients' age, gender, oral habit, cancer location, clinical stage, tumor size and lymph node status. Kaplan-Meier curves showed that oral SCC patients with positive pc-Jun staining or positive lymph node metastasis had significantly shorter overall survival (p < 0.018 and 0.001, respectively, by log-rank test).
Conclusion: These results indicate that c-Jun activation may play an important role in the carcinogenesis of oral SCC. Positive pc-Jun staining may serve as an adjuvant marker of worse prognosis in patients with oral SCC in Taiwan. |
topic |
c-Jun activation oral cancer prognosis |
url |
http://www.sciencedirect.com/science/article/pii/S0929664609603107 |
work_keys_str_mv |
AT ruchengkuo prognosticroleofcjunactivationinpatientswitharecaquidchewingrelatedoralsquamouscellcarcinomasintaiwan AT chiaoyinglin prognosticroleofcjunactivationinpatientswitharecaquidchewingrelatedoralsquamouscellcarcinomasintaiwan AT markyenpingkuo prognosticroleofcjunactivationinpatientswitharecaquidchewingrelatedoralsquamouscellcarcinomasintaiwan |
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