The Cuprizone Model: Dos and Do Nots

The Cuprizone Model: Dos and Do Nots

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic...

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Bibliographic Details
Main Authors: Jiangshan Zhan, Teresa Mann, Sarah Joost, Newshan Behrangi, Marcus Frank, Markus Kipp
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
multiple sclerosis
cuprizone model
histological analyses
Online Access:https://www.mdpi.com/2073-4409/9/4/843
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spelling doaj-b06286385cb44f1fba30e72cbf5b98442020-11-25T02:23:05ZengMDPI AGCells2073-44092020-03-01984384310.3390/cells9040843The Cuprizone Model: Dos and Do NotsJiangshan Zhan0Teresa Mann1Sarah Joost2Newshan Behrangi3Marcus Frank4Markus Kipp5Institute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, GermanyMedical Biology and Electron Microscopy Center, Rostock University Medical Center, Strempelstraße 14, 18057 Rostock, GermanyInstitute of Anatomy, Rostock University Medical Center, Gertrudenstrasse 9, 18057 Rostock, GermanyMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic demyelination induced by cuprizone has become more and more popular, and it has contributed substantially to our understanding of distinct yet important aspects of the MS pathology. Here, we aim to provide a practical guide on how to use the cuprizone model and which pitfalls should be avoided.https://www.mdpi.com/2073-4409/9/4/843multiple sclerosiscuprizone modelhistological analyses
collection DOAJ
language English
format Article
sources DOAJ
author Jiangshan Zhan
Teresa Mann
Sarah Joost
Newshan Behrangi
Marcus Frank
Markus Kipp
spellingShingle Jiangshan Zhan
Teresa Mann
Sarah Joost
Newshan Behrangi
Marcus Frank
Markus Kipp
The Cuprizone Model: Dos and Do Nots
Cells
multiple sclerosis
cuprizone model
histological analyses
author_facet Jiangshan Zhan
Teresa Mann
Sarah Joost
Newshan Behrangi
Marcus Frank
Markus Kipp
author_sort Jiangshan Zhan
title The Cuprizone Model: Dos and Do Nots
title_short The Cuprizone Model: Dos and Do Nots
title_full The Cuprizone Model: Dos and Do Nots
title_fullStr The Cuprizone Model: Dos and Do Nots
title_full_unstemmed The Cuprizone Model: Dos and Do Nots
title_sort cuprizone model: dos and do nots
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-03-01
description Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. During the last decade, the model of toxic demyelination induced by cuprizone has become more and more popular, and it has contributed substantially to our understanding of distinct yet important aspects of the MS pathology. Here, we aim to provide a practical guide on how to use the cuprizone model and which pitfalls should be avoided.
topic multiple sclerosis
cuprizone model
histological analyses
url https://www.mdpi.com/2073-4409/9/4/843
work_keys_str_mv AT jiangshanzhan thecuprizonemodeldosanddonots
AT teresamann thecuprizonemodeldosanddonots
AT sarahjoost thecuprizonemodeldosanddonots
AT newshanbehrangi thecuprizonemodeldosanddonots
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