Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition
Melanotan II (MTII), a synthetic analogue of the alpha-melanocyte stimulating hormone (α-MSH), has been applied for skin tanning in humans. However, the carcinogenic consequence of topical MTII has been equivocal. This study aims to delineate the anti-neoplastic efficacy and mechanism of MT...
Main Authors: | Jian-Ching Wu, Han-En Tsai, Yi-Hsiang Hsiao, Ji-Syuan Wu, Chieh-Shan Wu, Ming-Hong Tai |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-01-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/2/681 |
Similar Items
-
The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response
by: Rita Cabrita, et al.
Published: (2020-03-01) -
Characterizing the Roles of BRAF, PTEN and Cdkn2a in Novel Mouse Models of Melanoma Formation and Progression
by: Curley, David
Published: (2008) -
CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma
by: Walaa Hamed Shaker Nasry, et al.
Published: (2018-08-01) -
Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination
by: M. A. Taipov, et al.
Published: (2014-07-01) -
Annexin A7 Regulates Endometrial Receptivity
by: Md Alauddin, et al.
Published: (2020-08-01)