First insights in the genetics of caseous lymphadenitis in goats
Abscesses are a common problem in goat farms worldwide. In most cases, the disease is caused by Corynebacterium pseudotuberculosis that is the aetiological agent of caseous lymphadenitis (CLA). CLA causes considerable economic losses, due to reduced milk production, and to carcase damage. At present...
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doaj-b065db0640924e468c0faaaac349e43e2020-11-25T01:35:06ZengTaylor & Francis GroupItalian Journal of Animal Science1828-051X2017-01-01161313810.1080/1828051X.2016.12506101250610First insights in the genetics of caseous lymphadenitis in goatsGiulietta Minozzi0Silvana Mattiello1Lilia Grosso2Paola Crepaldi3Stefania Chessa4Giulio Pagnacco5Università degli Studi di MilanoUniversità degli Studi di MilanoUniversità degli Studi di MilanoUniversità degli Studi di MilanoIstituto di Biologia e Biotecnologia AgrariaUniversità degli Studi di MilanoAbscesses are a common problem in goat farms worldwide. In most cases, the disease is caused by Corynebacterium pseudotuberculosis that is the aetiological agent of caseous lymphadenitis (CLA). CLA causes considerable economic losses, due to reduced milk production, and to carcase damage. At present, no effective therapy for CLA is available and vaccine use is limited. The current study presents evidence for loci associated to CLA susceptibility identified using the 50K Goat SNP panel in a case-control genome wide association study. The analysis of the genotype data identified four chromosomal regions associated with disease status: on chromosomes 5, 7, 8 and 11. These results provide the first evidence for genetic loci involved in the immunological response to CLA in goat. Knowledge of genetic variations related to susceptibility will facilitate the incorporation of this information for the improvement of health status in the goat species.http://dx.doi.org/10.1080/1828051X.2016.1250610Caseous lymphadenitisgoatgenetic markersgenome wide association studygenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giulietta Minozzi Silvana Mattiello Lilia Grosso Paola Crepaldi Stefania Chessa Giulio Pagnacco |
spellingShingle |
Giulietta Minozzi Silvana Mattiello Lilia Grosso Paola Crepaldi Stefania Chessa Giulio Pagnacco First insights in the genetics of caseous lymphadenitis in goats Italian Journal of Animal Science Caseous lymphadenitis goat genetic markers genome wide association study genetics |
author_facet |
Giulietta Minozzi Silvana Mattiello Lilia Grosso Paola Crepaldi Stefania Chessa Giulio Pagnacco |
author_sort |
Giulietta Minozzi |
title |
First insights in the genetics of caseous lymphadenitis in goats |
title_short |
First insights in the genetics of caseous lymphadenitis in goats |
title_full |
First insights in the genetics of caseous lymphadenitis in goats |
title_fullStr |
First insights in the genetics of caseous lymphadenitis in goats |
title_full_unstemmed |
First insights in the genetics of caseous lymphadenitis in goats |
title_sort |
first insights in the genetics of caseous lymphadenitis in goats |
publisher |
Taylor & Francis Group |
series |
Italian Journal of Animal Science |
issn |
1828-051X |
publishDate |
2017-01-01 |
description |
Abscesses are a common problem in goat farms worldwide. In most cases, the disease is caused by Corynebacterium pseudotuberculosis that is the aetiological agent of caseous lymphadenitis (CLA). CLA causes considerable economic losses, due to reduced milk production, and to carcase damage. At present, no effective therapy for CLA is available and vaccine use is limited. The current study presents evidence for loci associated to CLA susceptibility identified using the 50K Goat SNP panel in a case-control genome wide association study. The analysis of the genotype data identified four chromosomal regions associated with disease status: on chromosomes 5, 7, 8 and 11. These results provide the first evidence for genetic loci involved in the immunological response to CLA in goat. Knowledge of genetic variations related to susceptibility will facilitate the incorporation of this information for the improvement of health status in the goat species. |
topic |
Caseous lymphadenitis goat genetic markers genome wide association study genetics |
url |
http://dx.doi.org/10.1080/1828051X.2016.1250610 |
work_keys_str_mv |
AT giuliettaminozzi firstinsightsinthegeneticsofcaseouslymphadenitisingoats AT silvanamattiello firstinsightsinthegeneticsofcaseouslymphadenitisingoats AT liliagrosso firstinsightsinthegeneticsofcaseouslymphadenitisingoats AT paolacrepaldi firstinsightsinthegeneticsofcaseouslymphadenitisingoats AT stefaniachessa firstinsightsinthegeneticsofcaseouslymphadenitisingoats AT giuliopagnacco firstinsightsinthegeneticsofcaseouslymphadenitisingoats |
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1725068502908272640 |