Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models
Recently, several clinical trials have been published to discuss the possibility of probiotic supplementation, especially some products of lactic acid bacteria such as Lactobacillus and Bifidobacterium strains, in prevention and treatment of allergic disorders. However, the results of some investiga...
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doaj-b06d53272fd041c9931722d7a3302cf72020-11-25T00:15:31ZengElsevierAllergology International1323-89302005-01-0154336737210.2332/allergolint.54.367Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse ModelsTakashi Shimada0Lei Cheng1Chie Motonaga2Hai-Bo Shi3Akiko Yamasaki4Tadao Enomoto5Taro Shirakawa6Central Research Laboratories, Nichinichi Pharmaceutical Co. Ltd., MieDivision of Molecular Allergology, International Research Centre for Nasal Allergy, Nanjing, China & Miyagi, JapanCentral Research Laboratories, Nichinichi Pharmaceutical Co. Ltd., MieDivision of Molecular Allergology, International Research Centre for Nasal Allergy, Nanjing, China & Miyagi, JapanDepartment of Health Promotion and Human Behavior, Kyoto University Graduate School of Public Health, KyotoDepartment of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, JapanDivision of Molecular Allergology, International Research Centre for Nasal Allergy, Nanjing, China & Miyagi, JapanRecently, several clinical trials have been published to discuss the possibility of probiotic supplementation, especially some products of lactic acid bacteria such as Lactobacillus and Bifidobacterium strains, in prevention and treatment of allergic disorders. However, the results of some investigations were inconsistent with each other. The contradictory effect of probiotics among different individuals might suggest differences in genetic or environmental factors, or both. It is conceivably beneficial to use inbred mice as experimental models to explore whether the effect of probiotics on limiting allergy is under the influence of genetic factors. In this review, firstly, we summarized recent publications regarding the effects of lysed Enterococcus faecalis FK-23 (LFK), which is a preparation of a probiotic lactic acid bacterium strain, on suppressing allergic responses in BALB/c mice. And then, we presented our latest data focused on the effects of LFK on suppressing active cutaneous anaphylaxis and local accumulation of eosinophils in four inbred mouse models by using the BALB/c, C57BL/ 6, C3H/HeN and C3H/HeJ strains. The finding of our experimental study suggests that the effect of LFK on combating allergic inflammatory reactions might be affect by individuals’ hereditary background.http://www.sciencedirect.com/science/article/pii/S1323893015310479active cutaneous anaphylaxisallergyEnterococcus faecaliseosinophilslactic acid bacteriamouse strains |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi Shimada Lei Cheng Chie Motonaga Hai-Bo Shi Akiko Yamasaki Tadao Enomoto Taro Shirakawa |
spellingShingle |
Takashi Shimada Lei Cheng Chie Motonaga Hai-Bo Shi Akiko Yamasaki Tadao Enomoto Taro Shirakawa Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models Allergology International active cutaneous anaphylaxis allergy Enterococcus faecalis eosinophils lactic acid bacteria mouse strains |
author_facet |
Takashi Shimada Lei Cheng Chie Motonaga Hai-Bo Shi Akiko Yamasaki Tadao Enomoto Taro Shirakawa |
author_sort |
Takashi Shimada |
title |
Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models |
title_short |
Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models |
title_full |
Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models |
title_fullStr |
Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models |
title_full_unstemmed |
Lysed Enterococcus faecalis FK-23 (LFK) Suppressing Allergic Responses in Mouse Models |
title_sort |
lysed enterococcus faecalis fk-23 (lfk) suppressing allergic responses in mouse models |
publisher |
Elsevier |
series |
Allergology International |
issn |
1323-8930 |
publishDate |
2005-01-01 |
description |
Recently, several clinical trials have been published to discuss the possibility of probiotic supplementation, especially some products of lactic acid bacteria such as Lactobacillus and Bifidobacterium strains, in prevention and treatment of allergic disorders. However, the results of some investigations were inconsistent with each other. The contradictory effect of probiotics among different individuals might suggest differences in genetic or environmental factors, or both. It is conceivably beneficial to use inbred mice as experimental models to explore whether the effect of probiotics on limiting allergy is under the influence of genetic factors. In this review, firstly, we summarized recent publications regarding the effects of lysed Enterococcus faecalis FK-23 (LFK), which is a preparation of a probiotic lactic acid bacterium strain, on suppressing allergic responses in BALB/c mice. And then, we presented our latest data focused on the effects of LFK on suppressing active cutaneous anaphylaxis and local accumulation of eosinophils in four inbred mouse models by using the BALB/c, C57BL/ 6, C3H/HeN and C3H/HeJ strains. The finding of our experimental study suggests that the effect of LFK on combating allergic inflammatory reactions might be affect by individuals’ hereditary background. |
topic |
active cutaneous anaphylaxis allergy Enterococcus faecalis eosinophils lactic acid bacteria mouse strains |
url |
http://www.sciencedirect.com/science/article/pii/S1323893015310479 |
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