Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation
The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was pla...
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doaj-b06ff1beb71344fa82b04ee339c4a6ae2020-11-25T01:38:58ZengMDPI AGMolecules1420-30492020-01-0125231810.3390/molecules25020318molecules25020318Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly FormulationCinzia Pagano0Maura Marinozzi1Claudio Baiocchi2Tommaso Beccari3Paola Calarco4Maria Rachele Ceccarini5Michela Chielli6Ciriana Orabona7Elena Orecchini8Roberta Ortenzi9Maurizio Ricci10Stefania Scuota11Maria Cristina Tiralti12Luana Perioli13Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Molecular Biotechnology and Health Sciences, Sect. Analytical Chemistry, Via Pietro Giuria 5, 10125 Torino, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Experimental Medicine, Sect. Pharmacology, University of Perugia, P.le L. Severi 1, Bld C/4th floor, 06132 Perugia, ItalyDepartment of Experimental Medicine, Sect. Pharmacology, University of Perugia, P.le L. Severi 1, Bld C/4th floor, 06132 Perugia, ItalyIstituto Zooprofilattico dell’Umbria e delle Marche, via G. Salvemini, 1, 06126 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyIstituto Zooprofilattico dell’Umbria e delle Marche, via G. Salvemini, 1, 06126 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123 Perugia, ItalyThe onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment.https://www.mdpi.com/1420-3049/25/2/318onion skins extracthydrogelpolymeric filmsanti-inflammatoryantibacterial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cinzia Pagano Maura Marinozzi Claudio Baiocchi Tommaso Beccari Paola Calarco Maria Rachele Ceccarini Michela Chielli Ciriana Orabona Elena Orecchini Roberta Ortenzi Maurizio Ricci Stefania Scuota Maria Cristina Tiralti Luana Perioli |
spellingShingle |
Cinzia Pagano Maura Marinozzi Claudio Baiocchi Tommaso Beccari Paola Calarco Maria Rachele Ceccarini Michela Chielli Ciriana Orabona Elena Orecchini Roberta Ortenzi Maurizio Ricci Stefania Scuota Maria Cristina Tiralti Luana Perioli Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation Molecules onion skins extract hydrogel polymeric films anti-inflammatory antibacterial |
author_facet |
Cinzia Pagano Maura Marinozzi Claudio Baiocchi Tommaso Beccari Paola Calarco Maria Rachele Ceccarini Michela Chielli Ciriana Orabona Elena Orecchini Roberta Ortenzi Maurizio Ricci Stefania Scuota Maria Cristina Tiralti Luana Perioli |
author_sort |
Cinzia Pagano |
title |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation |
title_short |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation |
title_full |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation |
title_fullStr |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation |
title_full_unstemmed |
Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation |
title_sort |
bioadhesive polymeric films based on red onion skins extract for wound treatment: an innovative and eco-friendly formulation |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-01-01 |
description |
The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment. |
topic |
onion skins extract hydrogel polymeric films anti-inflammatory antibacterial |
url |
https://www.mdpi.com/1420-3049/25/2/318 |
work_keys_str_mv |
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