Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds
<i>Coriandrum sativum</i> L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fracti...
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doaj-b070ca419b74478186ddf6307e13a2f72021-01-19T00:04:28ZengMDPI AGMolecules1420-30492021-01-012648748710.3390/molecules26020487Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander SeedsHamza Mechchate0Imane Es-safi1Amal Amaghnouje2Smahane Boukhira3Amal A. Alotaibi4Mohammed Al-zharani5Fahd A. Nasr6Omar M. Noman7Raffaele Conte8El Hamsas El Youbi Amal9Hicham Bekkari10Dalila Bousta11Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, MoroccoBasic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi ArabiaBiology Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaMedicinal Aromatic, and Poisonous Plants Research Centre, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaMedicinal Aromatic, and Poisonous Plants Research Centre, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaResearch Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, ItalyLaboratory of Biology and Health, Faculty of Sciences Ben M’Sik, Hassan II-Casablanca University, Casablanca 20000, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, Morocco<i>Coriandrum sativum</i> L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction of <i>Coriandrum sativum</i> seeds (PCS). Diabetic mice were orally administered with PCS (25 and 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along with the anti-inflammatory effect, assessed by measuring paw edema development induced with carrageenan in Wistar rat and the antioxidant activity assessed using two tests (β-carotene discoloration and DPPH). Treatment of diabetic mice with PCS for four weeks managed their high fasting blood glucose levels, improved their overall health, also revealed an excellent antihyperlipidemic activity. The OGTT result showed a potent antihyperglycemic activity, and following the anti-inflammatory and antioxidant effects, the PCS exhibited a perfect activity. LC-MS/MS result revealed the presence of 9 polyphenols. This modest work indicates that the PCS have an important antidiabetic, antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant effect that can be well established treatment of diabetes and its complications.https://www.mdpi.com/1420-3049/26/2/487<i>Coriandrum sativum</i> L.polyphenolsantioxidant proprietyanti-inflammatoryantidiabeticantihyperlipidemic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hamza Mechchate Imane Es-safi Amal Amaghnouje Smahane Boukhira Amal A. Alotaibi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Raffaele Conte El Hamsas El Youbi Amal Hicham Bekkari Dalila Bousta |
spellingShingle |
Hamza Mechchate Imane Es-safi Amal Amaghnouje Smahane Boukhira Amal A. Alotaibi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Raffaele Conte El Hamsas El Youbi Amal Hicham Bekkari Dalila Bousta Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds Molecules <i>Coriandrum sativum</i> L. polyphenols antioxidant propriety anti-inflammatory antidiabetic antihyperlipidemic |
author_facet |
Hamza Mechchate Imane Es-safi Amal Amaghnouje Smahane Boukhira Amal A. Alotaibi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Raffaele Conte El Hamsas El Youbi Amal Hicham Bekkari Dalila Bousta |
author_sort |
Hamza Mechchate |
title |
Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
title_short |
Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
title_full |
Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
title_fullStr |
Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
title_full_unstemmed |
Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds |
title_sort |
antioxidant, anti-inflammatory and antidiabetic proprieties of lc-ms/ms identified polyphenols from coriander seeds |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-01-01 |
description |
<i>Coriandrum sativum</i> L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction of <i>Coriandrum sativum</i> seeds (PCS). Diabetic mice were orally administered with PCS (25 and 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along with the anti-inflammatory effect, assessed by measuring paw edema development induced with carrageenan in Wistar rat and the antioxidant activity assessed using two tests (β-carotene discoloration and DPPH). Treatment of diabetic mice with PCS for four weeks managed their high fasting blood glucose levels, improved their overall health, also revealed an excellent antihyperlipidemic activity. The OGTT result showed a potent antihyperglycemic activity, and following the anti-inflammatory and antioxidant effects, the PCS exhibited a perfect activity. LC-MS/MS result revealed the presence of 9 polyphenols. This modest work indicates that the PCS have an important antidiabetic, antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant effect that can be well established treatment of diabetes and its complications. |
topic |
<i>Coriandrum sativum</i> L. polyphenols antioxidant propriety anti-inflammatory antidiabetic antihyperlipidemic |
url |
https://www.mdpi.com/1420-3049/26/2/487 |
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