Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones
Optogenetics provide a potential alternative approach to the treatment of chronic pain, in which complex pathology often hampers efficacy of standard pharmacological approaches. Technological advancements in the development of thin, wireless, and mechanically flexible optoelectronic implants offer n...
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doaj-b07ed6156ce645c2b7e2fd8b932a0b932020-11-24T21:49:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-09-011310.3389/fnins.2019.00819466053Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell PhonesPhilipp Mayer0Philipp Mayer1Nandhini Sivakumar2Michael Pritz3Matjia Varga4Andreas Mehmann5Seunghyun Lee6Alfredo Salvatore7Michele Magno8Matt Pharr9Helge C. Johannssen10Gerhard Troester11Hanns Ulrich Zeilhofer12Giovanni Antonio Salvatore13Giovanni Antonio Salvatore14Electronics Laboratory, ETH Zurich, Zurich, SwitzerlandInstitute for Integrated Circuits, ETH Zurich, Zurich, SwitzerlandInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, SwitzerlandElectronics Laboratory, ETH Zurich, Zurich, SwitzerlandElectronics Laboratory, ETH Zurich, Zurich, SwitzerlandElectronics Laboratory, ETH Zurich, Zurich, SwitzerlandDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, United StatesSensor ID, Campochiaro, ItalyInstitute for Integrated Circuits, ETH Zurich, Zurich, SwitzerlandDepartment of Mechanical Engineering, Texas A&M University, College Station, TX, United StatesInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, SwitzerlandElectronics Laboratory, ETH Zurich, Zurich, SwitzerlandInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, SwitzerlandElectronics Laboratory, ETH Zurich, Zurich, SwitzerlandSalvatore Optopharma, Zurich, SwitzerlandOptogenetics provide a potential alternative approach to the treatment of chronic pain, in which complex pathology often hampers efficacy of standard pharmacological approaches. Technological advancements in the development of thin, wireless, and mechanically flexible optoelectronic implants offer new routes to control the activity of subsets of neurons and nerve fibers in vivo. This study reports a novel and advanced design of battery-free, flexible, and lightweight devices equipped with one or two miniaturized LEDs, which can be individually controlled in real time. Two proof-of-concept experiments in mice demonstrate the feasibility of these devices. First, we show that blue-light devices implanted on top of the lumbar spinal cord can excite channelrhodopsin expressing nociceptors to induce place aversion. Second, we show that nocifensive withdrawal responses can be suppressed by green-light optogenetic (Archaerhodopsin-mediated) inhibition of action potential propagation along the sciatic nerve. One salient feature of these devices is that they can be operated via modern tablets and smartphones without bulky and complex lab instrumentation. In addition to the optical stimulation, the design enables the simultaneously wireless recording of the temperature in proximity of the stimulation area. As such, these devices are primed for translation to human patients with implications in the treatment of neurological and psychiatric conditions far beyond chronic pain syndromes.https://www.frontiersin.org/article/10.3389/fnins.2019.00819/fullwirelessflexible electronicsoptogeneticsin vivo experimentsnociceptionpain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philipp Mayer Philipp Mayer Nandhini Sivakumar Michael Pritz Matjia Varga Andreas Mehmann Seunghyun Lee Alfredo Salvatore Michele Magno Matt Pharr Helge C. Johannssen Gerhard Troester Hanns Ulrich Zeilhofer Giovanni Antonio Salvatore Giovanni Antonio Salvatore |
spellingShingle |
Philipp Mayer Philipp Mayer Nandhini Sivakumar Michael Pritz Matjia Varga Andreas Mehmann Seunghyun Lee Alfredo Salvatore Michele Magno Matt Pharr Helge C. Johannssen Gerhard Troester Hanns Ulrich Zeilhofer Giovanni Antonio Salvatore Giovanni Antonio Salvatore Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones Frontiers in Neuroscience wireless flexible electronics optogenetics in vivo experiments nociception pain |
author_facet |
Philipp Mayer Philipp Mayer Nandhini Sivakumar Michael Pritz Matjia Varga Andreas Mehmann Seunghyun Lee Alfredo Salvatore Michele Magno Matt Pharr Helge C. Johannssen Gerhard Troester Hanns Ulrich Zeilhofer Giovanni Antonio Salvatore Giovanni Antonio Salvatore |
author_sort |
Philipp Mayer |
title |
Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones |
title_short |
Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones |
title_full |
Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones |
title_fullStr |
Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones |
title_full_unstemmed |
Flexible and Lightweight Devices for Wireless Multi-Color Optogenetic Experiments Controllable via Commercial Cell Phones |
title_sort |
flexible and lightweight devices for wireless multi-color optogenetic experiments controllable via commercial cell phones |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2019-09-01 |
description |
Optogenetics provide a potential alternative approach to the treatment of chronic pain, in which complex pathology often hampers efficacy of standard pharmacological approaches. Technological advancements in the development of thin, wireless, and mechanically flexible optoelectronic implants offer new routes to control the activity of subsets of neurons and nerve fibers in vivo. This study reports a novel and advanced design of battery-free, flexible, and lightweight devices equipped with one or two miniaturized LEDs, which can be individually controlled in real time. Two proof-of-concept experiments in mice demonstrate the feasibility of these devices. First, we show that blue-light devices implanted on top of the lumbar spinal cord can excite channelrhodopsin expressing nociceptors to induce place aversion. Second, we show that nocifensive withdrawal responses can be suppressed by green-light optogenetic (Archaerhodopsin-mediated) inhibition of action potential propagation along the sciatic nerve. One salient feature of these devices is that they can be operated via modern tablets and smartphones without bulky and complex lab instrumentation. In addition to the optical stimulation, the design enables the simultaneously wireless recording of the temperature in proximity of the stimulation area. As such, these devices are primed for translation to human patients with implications in the treatment of neurological and psychiatric conditions far beyond chronic pain syndromes. |
topic |
wireless flexible electronics optogenetics in vivo experiments nociception pain |
url |
https://www.frontiersin.org/article/10.3389/fnins.2019.00819/full |
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