Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of fin...

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Main Authors:	Yujia Xia, Zachary J. Brown, Hai Huang, Allan Tsung
Format:	Article
Language:	English
Published:	Wiley 2021-09-01
Series:	Cancer Medicine
Subjects:	hepatocellular carcinoma immune cells metabolic reprogramming tumor immunology tumor microenvironment
Online Access:	https://doi.org/10.1002/cam4.4177

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spelling	doaj-b082632c34dd4674bada681fc476f23f2021-09-17T05:24:01ZengWileyCancer Medicine2045-76342021-09-0110186374638310.1002/cam4.4177Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinomaYujia Xia0Zachary J. Brown1Hai Huang2Allan Tsung3Division of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USADivision of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USADivision of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USADivision of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH USAAbstract Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.https://doi.org/10.1002/cam4.4177hepatocellular carcinomaimmune cellsmetabolic reprogrammingtumor immunologytumor microenvironment
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yujia Xia Zachary J. Brown Hai Huang Allan Tsung
spellingShingle	Yujia Xia Zachary J. Brown Hai Huang Allan Tsung Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma Cancer Medicine hepatocellular carcinoma immune cells metabolic reprogramming tumor immunology tumor microenvironment
author_facet	Yujia Xia Zachary J. Brown Hai Huang Allan Tsung
author_sort	Yujia Xia
title	Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_short	Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_full	Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_fullStr	Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_full_unstemmed	Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_sort	metabolic reprogramming of immune cells: shaping the tumor microenvironment in hepatocellular carcinoma
publisher	Wiley
series	Cancer Medicine
issn	2045-7634
publishDate	2021-09-01
description	Abstract Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.
topic	hepatocellular carcinoma immune cells metabolic reprogramming tumor immunology tumor microenvironment
url	https://doi.org/10.1002/cam4.4177
work_keys_str_mv	AT yujiaxia metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma AT zacharyjbrown metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma AT haihuang metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma AT allantsung metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma
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Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

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