Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice

Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice

Accumulating data demonstrated that hepatic endoplasmic reticulum (ER) stress was involved in the pathogenesis of liver fibrosis. Long-term chronic hepatocyte death contributed to liver fibrosis initiation and progression. Previous researches reported that ER stress sensor inositol-requiring enzyme...

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Bibliographic Details
Main Authors: Qian-Qian Chen, Cheng Zhang, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu, Jian-Qing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
inositol-requiring enzyme 1 alpha
STF-083010
miR-122
hepatocyte death
liver fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01344/full

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