Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile
Background / Aims:Clostridium difficile is a Gram-positive, strict anaerobe, spore-forming bacterium. It can cause self-limiting mild diarrhea, severe diarrhea, pseudomembranous colitis, and fatal fulminant colitis. We aimed to investigate the changes in epidemiology and incidence of C. difficile...
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doaj-b093ef578bf34aadbbee6e81bdfc243d2020-11-25T01:54:34ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492019-01-012560010.4103/sjg.SJG_44_19Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficileSibel BolukcuIsmail Necati HakyemezBilge Sumbul GultepeGulay OkayBulent DurduMeliha Meric KocTuran AslanBackground / Aims:Clostridium difficile is a Gram-positive, strict anaerobe, spore-forming bacterium. It can cause self-limiting mild diarrhea, severe diarrhea, pseudomembranous colitis, and fatal fulminant colitis. We aimed to investigate the changes in epidemiology and incidence of C. difficile infection in our hospital database. Patients and Methods: Episodes of C. difficile toxin were identified in hospital database, and data such as age, sex, community versus hospital acquisition, intensive care follow-up, current or previous treatments with antibiotics within the past 3 months, medication with proton pump inhibitors, or immunosuppressive therapies were collected. Results: Toxin-positive 78 individuals constituted the patient group. In univariate analyses, independent risk factors for toxin positivity were community versus hospital acquisition [odds ratio (OR), 5.49; 95% confidence interval (CI), 2.52–11.95; P = 0.0001], presence of inflammatory bowel diseases (IBDs) (OR, 21.5; 95% CI, 8.65–53.44; P = 0.0001), proton pump inhibitors' use (OR, 4.53; 95% CI, 1.97–10.43; P = 0.0001), immunosuppressive drug use (OR, 4.1; 95% CI, 2.01–8.3; P = 0.0001), and use of quinolone group of antibiotics (OR, 5.95; 95% CI, 1.92–18.46; P = 0.001). Antibiotic use was a protective risk factor (OR, 0.09; 95% CI, 0.01–0.78; P = 0.01) and presence of IBDs was an independent risk factor (OR, 6.8; 95% CI, 1.5–30.08; P = 0.01) in community-acquired group (OR, 0.09; 95% CI, 0.01–0.78; P = 0.01). Conclusion: In recent studies, C. difficile infections were demonstrated to be more frequent in younger individuals who did not have a history of hospitalization but had an underlying disease such as IBD. In our study, we showed the change in the epidemiological data with prominence of underlying diseases such as IBDs.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=6;spage=0;epage=0;aulast=Bolukcuantibioticsclostridium difficileinflammatory bowel diseaserisk factorsturkey |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sibel Bolukcu Ismail Necati Hakyemez Bilge Sumbul Gultepe Gulay Okay Bulent Durdu Meliha Meric Koc Turan Aslan |
spellingShingle |
Sibel Bolukcu Ismail Necati Hakyemez Bilge Sumbul Gultepe Gulay Okay Bulent Durdu Meliha Meric Koc Turan Aslan Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile The Saudi Journal of Gastroenterology antibiotics clostridium difficile inflammatory bowel disease risk factors turkey |
author_facet |
Sibel Bolukcu Ismail Necati Hakyemez Bilge Sumbul Gultepe Gulay Okay Bulent Durdu Meliha Meric Koc Turan Aslan |
author_sort |
Sibel Bolukcu |
title |
Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile |
title_short |
Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile |
title_full |
Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile |
title_fullStr |
Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile |
title_full_unstemmed |
Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile |
title_sort |
clostridium difficile infection: is there a change in the underlying factors? inflammatory bowel disease and clostridium difficile |
publisher |
Wolters Kluwer Medknow Publications |
series |
The Saudi Journal of Gastroenterology |
issn |
1319-3767 1998-4049 |
publishDate |
2019-01-01 |
description |
Background / Aims:Clostridium difficile is a Gram-positive, strict anaerobe, spore-forming bacterium. It can cause self-limiting mild diarrhea, severe diarrhea, pseudomembranous colitis, and fatal fulminant colitis. We aimed to investigate the changes in epidemiology and incidence of C. difficile infection in our hospital database.
Patients and Methods: Episodes of C. difficile toxin were identified in hospital database, and data such as age, sex, community versus hospital acquisition, intensive care follow-up, current or previous treatments with antibiotics within the past 3 months, medication with proton pump inhibitors, or immunosuppressive therapies were collected.
Results: Toxin-positive 78 individuals constituted the patient group. In univariate analyses, independent risk factors for toxin positivity were community versus hospital acquisition [odds ratio (OR), 5.49; 95% confidence interval (CI), 2.52–11.95; P = 0.0001], presence of inflammatory bowel diseases (IBDs) (OR, 21.5; 95% CI, 8.65–53.44; P = 0.0001), proton pump inhibitors' use (OR, 4.53; 95% CI, 1.97–10.43; P = 0.0001), immunosuppressive drug use (OR, 4.1; 95% CI, 2.01–8.3; P = 0.0001), and use of quinolone group of antibiotics (OR, 5.95; 95% CI, 1.92–18.46; P = 0.001). Antibiotic use was a protective risk factor (OR, 0.09; 95% CI, 0.01–0.78; P = 0.01) and presence of IBDs was an independent risk factor (OR, 6.8; 95% CI, 1.5–30.08; P = 0.01) in community-acquired group (OR, 0.09; 95% CI, 0.01–0.78; P = 0.01).
Conclusion: In recent studies, C. difficile infections were demonstrated to be more frequent in younger individuals who did not have a history of hospitalization but had an underlying disease such as IBD. In our study, we showed the change in the epidemiological data with prominence of underlying diseases such as IBDs. |
topic |
antibiotics clostridium difficile inflammatory bowel disease risk factors turkey |
url |
http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=6;spage=0;epage=0;aulast=Bolukcu |
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