Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation

• Main Authors: Stefanie Böhm, Christine Strauß, Stefan Stoiber, Cornelia Kasper, Verena Charwat
• Format: Article
• Language: English
• Published: MDPI AG 2017-09-01
• Series: Materials
• Subjects: collagen scaffolds; fibroblasts; platelet aggregation; 3D cell culture
• Online Access: https://www.mdpi.com/1996-1944/10/9/1086

Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process.