| Summary: | Objective: To explore the common mechanism of Huanglian Jiedu Decoction in treating
coronary heart disease and type 2 diabetes by network pharmacology. Methods: All chemical
components and targets of the four drugs in Huanglian Jiedu Decoction were retrieved through
TCMSP, and the genes were standardized through Uniprot database. Acquire disease targets
related to coronary heart disease and diabetes in OMIM and GeneCards databases. The
network diagram of "drug-component-target-disease" is constructed by using the software
of cytopscape 3.7.2, the PPI network diagram of protein interaction is constructed by using
STRING database, and the network diagram of "drug-disease" core target is constructed by
using the software of cytopscape 3.7.2. DAVID's online database platform was used to analyze
GO biological process and KEGG pathway enrichment of common targets of Huanglian
Jiedu Decoction in treating coronary heart disease and type 2 diabetes. Results: 103 active
ingredients of Huanglian Jiedu Decoction were retrieved, including 140 acting targets, 5342
coronary heart disease targets, 114 diabetes targets, and 14 common intersection targets
of drugs and diseases, involving AR, PPARG, TNF, IL6, CCL2, VEGFA, PON1, etc. The
GO biological process analysis results in 98 biological processes, 10 cell components and
10 molecular functions. Among them are positive regulation of gene expression, positive
regulation of nitric oxide biosynthesis process, Extracellular space, cytokine activity, steroid
hormone receptor activity and other biological processes; The enrichment analysis of KEGG
pathway yielded 20 signal pathways (P≤0.05). It mainly involves Malaria, cancer in cancer,
HIF-1 signaling pathway, TNF signaling pathway, NOD-like receptor signaling pathway,
PI3K-Akt signaling pathway, etc. Conclusion: Huanglian Jiedu Decoction "treats different
diseases at the same time" coronary heart disease and type 2 diabetes have the characteristics of
multiple components, multiple targets and multiple pathways, which provide theoretical basis
for Huanglian Jiedu Decoction to treat coronary heart disease and type 2 diabetes in clinic, but
the key targets and pathways of Huanglian Jiedu Decoction to treat diseases still need further
experimental verification.
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