Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neu...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-10-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.568574/full |
id |
doaj-b0b3f9f10ad241caa0e5d656fee63436 |
---|---|
record_format |
Article |
spelling |
doaj-b0b3f9f10ad241caa0e5d656fee634362020-11-25T03:39:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.568574568574Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various CancersYiting Chen0Yiting Chen1Jieling Ning2Wenjie Cao3Shuanglian Wang4Tao Du5Jiahui Jiang6Xueping Feng7Bin Zhang8Department of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, ChinaThioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and other diseases. Increasing evidence has shown that TXNIP expression is low in tumors and that it may act as a tumor suppressor in various cancer types such as hepatocarcinoma, breast cancer, and lung cancer. TXNIP is known to inhibit the proliferation of breast cancer cells by affecting metabolic reprogramming and can affect the invasion and migration of breast cancer cells through the TXNIP-HIF1α-TWIST signaling axis. TXNIP can also prevent the occurrence of bladder cancer by inhibiting the activation of ERK, which inhibits apoptosis in bladder cancer cells. In this review, we find that TXNIP can be regulated by binding to transcription factors or other binding proteins and can also be downregulated by epigenetic changes or miRNA. In addition, we also summarize emerging insights on TXNIP expression and its functional role in different kinds of cancers, as well as clarify its participation in metabolic reprogramming and oxidative stress in cancer cells, wherein it acts as a putative tumor suppressor gene to inhibit the proliferation, invasion, and migration of different tumor cells as well as promote apoptosis in these cells. TXNIP may therefore be of basic and clinical significance for finding novel molecular targets that can facilitate the diagnosis and treatment of malignant tumors.https://www.frontiersin.org/articles/10.3389/fonc.2020.568574/fullTXNIP (thioredoxin interacting protein)canceroxidative stressresearch progressclinical significance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiting Chen Yiting Chen Jieling Ning Wenjie Cao Shuanglian Wang Tao Du Jiahui Jiang Xueping Feng Bin Zhang |
spellingShingle |
Yiting Chen Yiting Chen Jieling Ning Wenjie Cao Shuanglian Wang Tao Du Jiahui Jiang Xueping Feng Bin Zhang Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers Frontiers in Oncology TXNIP (thioredoxin interacting protein) cancer oxidative stress research progress clinical significance |
author_facet |
Yiting Chen Yiting Chen Jieling Ning Wenjie Cao Shuanglian Wang Tao Du Jiahui Jiang Xueping Feng Bin Zhang |
author_sort |
Yiting Chen |
title |
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers |
title_short |
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers |
title_full |
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers |
title_fullStr |
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers |
title_full_unstemmed |
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers |
title_sort |
research progress of txnip as a tumor suppressor gene participating in the metabolic reprogramming and oxidative stress of cancer cells in various cancers |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-10-01 |
description |
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and other diseases. Increasing evidence has shown that TXNIP expression is low in tumors and that it may act as a tumor suppressor in various cancer types such as hepatocarcinoma, breast cancer, and lung cancer. TXNIP is known to inhibit the proliferation of breast cancer cells by affecting metabolic reprogramming and can affect the invasion and migration of breast cancer cells through the TXNIP-HIF1α-TWIST signaling axis. TXNIP can also prevent the occurrence of bladder cancer by inhibiting the activation of ERK, which inhibits apoptosis in bladder cancer cells. In this review, we find that TXNIP can be regulated by binding to transcription factors or other binding proteins and can also be downregulated by epigenetic changes or miRNA. In addition, we also summarize emerging insights on TXNIP expression and its functional role in different kinds of cancers, as well as clarify its participation in metabolic reprogramming and oxidative stress in cancer cells, wherein it acts as a putative tumor suppressor gene to inhibit the proliferation, invasion, and migration of different tumor cells as well as promote apoptosis in these cells. TXNIP may therefore be of basic and clinical significance for finding novel molecular targets that can facilitate the diagnosis and treatment of malignant tumors. |
topic |
TXNIP (thioredoxin interacting protein) cancer oxidative stress research progress clinical significance |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.568574/full |
work_keys_str_mv |
AT yitingchen researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT yitingchen researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT jielingning researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT wenjiecao researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT shuanglianwang researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT taodu researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT jiahuijiang researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT xuepingfeng researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers AT binzhang researchprogressoftxnipasatumorsuppressorgeneparticipatinginthemetabolicreprogrammingandoxidativestressofcancercellsinvariouscancers |
_version_ |
1724539898389594112 |