IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS
ABSTRACT Introduction: to report a case of bilateral leukemic retinopathy due to leukostasis that was successfully managed by leukapheresis. Case Presentation: 31-year-old male with mild visual disturbance was referred to ophthalmology department. He suffered from Chronic Myelogenous Leukemi...
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doaj-b0b84e65e9a64cf5a1343bd5c893cddd2020-11-25T03:06:46ZengInternational Journal of RetinaIJRETINA (International Journal of Retina)2614-86842614-85362020-02-013110.35479/ijretina.2020.vol003.iss001.87 IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASISRuchyta Ranti0Sauli Ari WidjajaWimbo SasonoMuhammad FirmansjahIma YustiariniAdy Dwi PrakosaMoestidjab MoestidjabGatut SuhendroUniversitas Airlangga ABSTRACT Introduction: to report a case of bilateral leukemic retinopathy due to leukostasis that was successfully managed by leukapheresis. Case Presentation: 31-year-old male with mild visual disturbance was referred to ophthalmology department. He suffered from Chronic Myelogenous Leukemia (CML) with white blood cell (WBC) count 533.900/microL. He was started on hydroxyurea, allopurinol, and once leukapheresis. Ophthalmologic evaluation revealed visual acuity of 4/4 in the right eye and 4/6,3 in the left eye. Funduscopy examination showed the presence of bilateral papilledema, venous engorgement, tortuosity, and retinal hemorrhages. Then this patient continued with second leukapheresis. Result: Visual acuity, laboratory examination, and funduscopic finding was evaluated. His visual acuity was improved, papilledema and retinal blood vessels abnormality had markedly reduced concurring with the patient’s hematological remission. Decreasing WBC count after leukapheresis has improved blood flow that reflected from the retinal findings and visual acuity improvement. Conclusion: Leukapheresis treatment is sufficient to improved clinical condition for leukemic retinopathy caused by CML with leukostasis. Keywords: chronic myelogenous leukemia (CML), hyperleukocytosis, leukostasis, leukemic retinopathy https://www.ijretina.com/index.php/ijretina/article/view/87 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruchyta Ranti Sauli Ari Widjaja Wimbo Sasono Muhammad Firmansjah Ima Yustiarini Ady Dwi Prakosa Moestidjab Moestidjab Gatut Suhendro |
spellingShingle |
Ruchyta Ranti Sauli Ari Widjaja Wimbo Sasono Muhammad Firmansjah Ima Yustiarini Ady Dwi Prakosa Moestidjab Moestidjab Gatut Suhendro IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS IJRETINA (International Journal of Retina) |
author_facet |
Ruchyta Ranti Sauli Ari Widjaja Wimbo Sasono Muhammad Firmansjah Ima Yustiarini Ady Dwi Prakosa Moestidjab Moestidjab Gatut Suhendro |
author_sort |
Ruchyta Ranti |
title |
IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS |
title_short |
IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS |
title_full |
IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS |
title_fullStr |
IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS |
title_full_unstemmed |
IMPROVEMENT OF LEUKEMIC RETINOPATHY AFTER LEUKAPHERESIS IN CHRONIC MYELOGENOUS LEUKEMIA WITH LEUKOSTASIS |
title_sort |
improvement of leukemic retinopathy after leukapheresis in chronic myelogenous leukemia with leukostasis |
publisher |
International Journal of Retina |
series |
IJRETINA (International Journal of Retina) |
issn |
2614-8684 2614-8536 |
publishDate |
2020-02-01 |
description |
ABSTRACT
Introduction: to report a case of bilateral leukemic retinopathy due to leukostasis that was successfully managed by leukapheresis.
Case Presentation: 31-year-old male with mild visual disturbance was referred to ophthalmology department. He suffered from Chronic Myelogenous Leukemia (CML) with white blood cell (WBC) count 533.900/microL. He was started on hydroxyurea, allopurinol, and once leukapheresis. Ophthalmologic evaluation revealed visual acuity of 4/4 in the right eye and 4/6,3 in the left eye. Funduscopy examination showed the presence of bilateral papilledema, venous engorgement, tortuosity, and retinal hemorrhages. Then this patient continued with second leukapheresis.
Result: Visual acuity, laboratory examination, and funduscopic finding was evaluated. His visual acuity was improved, papilledema and retinal blood vessels abnormality had markedly reduced concurring with the patient’s hematological remission. Decreasing WBC count after leukapheresis has improved blood flow that reflected from the retinal findings and visual acuity improvement.
Conclusion: Leukapheresis treatment is sufficient to improved clinical condition for leukemic retinopathy caused by CML with leukostasis.
Keywords: chronic myelogenous leukemia (CML), hyperleukocytosis, leukostasis, leukemic retinopathy
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url |
https://www.ijretina.com/index.php/ijretina/article/view/87 |
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