Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study.
BACKGROUND: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy. METHODS: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively anal...
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doaj-b0c135322f1e44378494fb9809e4d2052020-11-25T02:15:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4484210.1371/journal.pone.0044842Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study.Chieh-Mo LinShu-Min LinFu-Tsai ChungHorng-Chyuan LinKang-Yun LeeChien-Da HuangChih-Hsi KuoChien-Ying LiuChun-Hua WangHan-Pin KuoBACKGROUND: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy. METHODS: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed. RESULTS: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p<0.001). Patients with symptom duration <18 days prior to pleural effusion studies had more positive AMTD tests than those with symptom >18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011). CONCLUSIONS: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.http://europepmc.org/articles/PMC3438172?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chieh-Mo Lin Shu-Min Lin Fu-Tsai Chung Horng-Chyuan Lin Kang-Yun Lee Chien-Da Huang Chih-Hsi Kuo Chien-Ying Liu Chun-Hua Wang Han-Pin Kuo |
spellingShingle |
Chieh-Mo Lin Shu-Min Lin Fu-Tsai Chung Horng-Chyuan Lin Kang-Yun Lee Chien-Da Huang Chih-Hsi Kuo Chien-Ying Liu Chun-Hua Wang Han-Pin Kuo Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. PLoS ONE |
author_facet |
Chieh-Mo Lin Shu-Min Lin Fu-Tsai Chung Horng-Chyuan Lin Kang-Yun Lee Chien-Da Huang Chih-Hsi Kuo Chien-Ying Liu Chun-Hua Wang Han-Pin Kuo |
author_sort |
Chieh-Mo Lin |
title |
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
title_short |
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
title_full |
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
title_fullStr |
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
title_full_unstemmed |
Amplified Mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
title_sort |
amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy--a diagnostic accuracy study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
BACKGROUND: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy. METHODS: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed. RESULTS: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p<0.001). Patients with symptom duration <18 days prior to pleural effusion studies had more positive AMTD tests than those with symptom >18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011). CONCLUSIONS: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests. |
url |
http://europepmc.org/articles/PMC3438172?pdf=render |
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