Novel Graph-Based Model With Biaffine Attention for Family History Extraction From Clinical Text: Modeling Study

BackgroundFamily history information, including information on family members, side of the family of family members, living status of family members, and observations of family members, plays an important role in disease diagnosis and treatment. Family member information extr...

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Bibliographic Details
Main Authors: Zhan, Kecheng, Peng, Weihua, Xiong, Ying, Fu, Huhao, Chen, Qingcai, Wang, Xiaolong, Tang, Buzhou
Format: Article
Language:English
Published: JMIR Publications 2021-04-01
Series:JMIR Medical Informatics
Online Access:https://medinform.jmir.org/2021/4/e23587
Description
Summary:BackgroundFamily history information, including information on family members, side of the family of family members, living status of family members, and observations of family members, plays an important role in disease diagnosis and treatment. Family member information extraction aims to extract family history information from semistructured/unstructured text in electronic health records (EHRs), which is a challenging task regarding named entity recognition (NER) and relation extraction (RE), where named entities refer to family members, living status, and observations, and relations refer to relations between family members and living status, and relations between family members and observations. ObjectiveThis study aimed to introduce the system we developed for the 2019 n2c2/OHNLP track on family history extraction, which can jointly extract entities and relations about family history information from clinical text. MethodsWe proposed a novel graph-based model with biaffine attention for family history extraction from clinical text. In this model, we first designed a graph to represent family history information, that is, representing NER and RE regarding family history in a unified way, and then introduced a biaffine attention mechanism to extract family history information in clinical text. Convolution neural network (CNN)-Bidirectional Long Short Term Memory network (BiLSTM) and Bidirectional Encoder Representation from Transformers (BERT) were used to encode the input sentence, and a biaffine classifier was used to extract family history information. In addition, we developed a postprocessing module to adjust the results. A system based on the proposed method was developed for the 2019 n2c2/OHNLP shared task track on family history information extraction. ResultsOur system ranked first in the challenge, and the F1 scores of the best system on the NER subtask and RE subtask were 0.8745 and 0.6810, respectively. After the challenge, we further fine tuned the parameters and improved the F1 scores of the two subtasks to 0.8823 and 0.7048, respectively. ConclusionsThe experimental results showed that the system based on the proposed method can extract family history information from clinical text effectively.
ISSN:2291-9694