Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms and interactions among tumor and stromal cell...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Academya Publishing Co.
2016-12-01
|
Series: | Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-485.pdf |
id |
doaj-b0c7751bbf6e40f4a39b3f820eb4f065 |
---|---|
record_format |
Article |
spelling |
doaj-b0c7751bbf6e40f4a39b3f820eb4f0652020-11-24T23:29:36ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782016-12-0131448549210.3803/EnM.2016.31.4.48521709Osteoblasts Are the Centerpiece of the Metastatic Bone MicroenvironmentHyo Min JeongSun Wook ChoSerk In ParkThe tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms and interactions among tumor and stromal cells remain to be elucidated. Bone metastasis is the major problem in many types of human malignancies including prostate, breast and lung cancers, and the biological basis of bone metastasis let alone curative approaches are largely undetermined. Among the many types of stromal cells in bone, osteoblasts are shown to be an important player. In this regard, osteoblasts are a key target cell type in the development of bone metastasis, but there are currently no drugs or therapeutic approaches are available that specifically target osteoblasts. This review paper summarizes the current knowledge on osteoblasts in the metastatic tumor microenvironment, aiming to provide clues and directions for future research endeavor.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-485.pdfNeoplasmsNeoplasm metastasisBone and bonesMicroenvironmentOsteoblastsOsteoclasts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyo Min Jeong Sun Wook Cho Serk In Park |
spellingShingle |
Hyo Min Jeong Sun Wook Cho Serk In Park Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment Endocrinology and Metabolism Neoplasms Neoplasm metastasis Bone and bones Microenvironment Osteoblasts Osteoclasts |
author_facet |
Hyo Min Jeong Sun Wook Cho Serk In Park |
author_sort |
Hyo Min Jeong |
title |
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment |
title_short |
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment |
title_full |
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment |
title_fullStr |
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment |
title_full_unstemmed |
Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment |
title_sort |
osteoblasts are the centerpiece of the metastatic bone microenvironment |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2016-12-01 |
description |
The tumor microenvironment is comprised of diverse stromal cell populations in addition to tumor cells. Increasing evidence now clearly supports the role of microenvironment stromal cells in tumor progression and metastasis, yet the regulatory mechanisms and interactions among tumor and stromal cells remain to be elucidated. Bone metastasis is the major problem in many types of human malignancies including prostate, breast and lung cancers, and the biological basis of bone metastasis let alone curative approaches are largely undetermined. Among the many types of stromal cells in bone, osteoblasts are shown to be an important player. In this regard, osteoblasts are a key target cell type in the development of bone metastasis, but there are currently no drugs or therapeutic approaches are available that specifically target osteoblasts. This review paper summarizes the current knowledge on osteoblasts in the metastatic tumor microenvironment, aiming to provide clues and directions for future research endeavor. |
topic |
Neoplasms Neoplasm metastasis Bone and bones Microenvironment Osteoblasts Osteoclasts |
url |
http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-485.pdf |
work_keys_str_mv |
AT hyominjeong osteoblastsarethecenterpieceofthemetastaticbonemicroenvironment AT sunwookcho osteoblastsarethecenterpieceofthemetastaticbonemicroenvironment AT serkinpark osteoblastsarethecenterpieceofthemetastaticbonemicroenvironment |
_version_ |
1725544814058930176 |