and Antioxidant Activity of Endophytic Fungi from Mahogoni Plant (Swietenia macrophylla King

• Main Authors: Edward J Dompeipen, Partomuan Simanjuntak
• Format: Article
• Language: Indonesian
• Published: Balai Riset dan Standardisasi Industri Pontianak 2015-06-01
• Series: Biopropal Industri
• Subjects: antidiabetic; antioxidant; Swietenia macrophylla King; α-glucosidase; 2.2-diphenyl-1-picrylhydrazyl
• Online Access: http://ejournal.kemenperin.go.id/biopropal/article/view/829
• ISSN: 2089-0877; 2502-2962

Diabetes mellitus is a degenerative disease characterized by hyperglycemia due to insulin insulin deficiency either absoluteor relative. This study was conducted to isolate endophytic fungi from plant twigs mahogany (<em>Swietenia macrophylla</em> King) which active as antidiabetic and antioxidant. Antidiabetic activity conducted by using the α-glucosidase inhibitory and antioxidant activity using free radical reduction method with reagent 2.2-diphenyl-1-picrylhydrazyl (DPPH). Isolation of microbes conducted in the media Corn Meal Malt Agar (CMMA) and Potato Dextrose Agar (PDA) which 7 isolates of fungus in total. Inhibitory activity against α-glucosidase to extract the filtrate and biomass of the isolates A.Sm.2F (72.59 and 92.22%), A.Sm.3F (81.87 and 79.37%), B.Sm.1F (63.40 and 98.84%), B.Sm.2F (65.60 and 62.72%), B.Sm.3F (93.91 and 51.48%), B.Sm.4F (87.48 and 74.64%) thus has potential as an antidiabetic activity. B.Sm.1F was the only isolates active as antioxidants with IC₅₀ of 84.41.