The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes...
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Instituto de Tecnologia do Paraná (Tecpar)
2013-06-01
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doaj-b0d8f5bac9ad4c0b9bf089f6272b0fcc2020-11-24T21:15:40ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242013-06-0156340541110.1590/S1516-89132013000300008S1516-89132013000300008The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytesHasan Turkez0Elanur Aydin1Erzurum Teknik ÜniversitesAtaturk UniversityThe aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008&lng=en&tlng=enChromosome aberrationmutagenicitypermethrinresveratrolsister chromatid exchange |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hasan Turkez Elanur Aydin |
spellingShingle |
Hasan Turkez Elanur Aydin The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes Brazilian Archives of Biology and Technology Chromosome aberration mutagenicity permethrin resveratrol sister chromatid exchange |
author_facet |
Hasan Turkez Elanur Aydin |
author_sort |
Hasan Turkez |
title |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_short |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_full |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_fullStr |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_full_unstemmed |
The genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
title_sort |
genoprotective activity of resveratrol on permethrin-induced genotoxic damage in cultured human lymphocytes |
publisher |
Instituto de Tecnologia do Paraná (Tecpar) |
series |
Brazilian Archives of Biology and Technology |
issn |
1678-4324 |
publishDate |
2013-06-01 |
description |
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent. |
topic |
Chromosome aberration mutagenicity permethrin resveratrol sister chromatid exchange |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300008&lng=en&tlng=en |
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