Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation
Activation of the renin–angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi - SAGE Publishing
2011-12-01
|
Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320311399605 |
id |
doaj-b0dbb77b55ca432e819ce9275e1abea6 |
---|---|
record_format |
Article |
spelling |
doaj-b0dbb77b55ca432e819ce9275e1abea62021-05-02T19:10:54ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762011-12-011210.1177/1470320311399605Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillationNurdan Papila Topal0Beste Ozben1Veysel Sabri Hancer2Azra Meryem Tanrikulu3Reyhan Diz-Kucukkaya4Ali Serdar Fak5Yelda Basaran6Osman Yesildag7Marmara University, Faculty of Medicine, Department of Cardiology, Istanbul, TurkeyMarmara University, Faculty of Medicine, Department of Cardiology, Istanbul, TurkeyIstanbul Bilim University, Faculty of Medicine, Department of Medical Biology and Genetics, Istanbul, TurkeyMarmara University, Faculty of Medicine, Department of Cardiology, Istanbul, TurkeyIstanbul Bilim University, Faculty of Medicine, Department of Internal Medicine, Division of Haematology, Istanbul, TurkeyMarmara University, Faculty of Medicine, Department of General Medicine, Istanbul, TurkeyMarmara University, Faculty of Medicine, Department of Cardiology, Istanbul, TurkeyMarmara University, Faculty of Medicine, Department of Cardiology, Istanbul, TurkeyActivation of the renin–angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were consecutively recruited into the study. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and the M235T, A-20C, and G-6A polymorphisms of the angiotensinogen gene were genotyped. Patients with AF had significantly lower frequency of II genotype of ACE I/D and higher frequency of angiotensinogen M235T polymorphism T allele and TT genotype and G-6A polymorphism G allele and GG genotype compared with the controls. AF patients had significantly larger left atrium, higher left ventricular mass index (LVMI) and higher frequency of significant valvular pathology. ACE I/D polymorphism II genotype, angiotensinogen M235T polymorphism TT genotype and G allele and GG genotype of angiotensinogen G-6A polymorphism were still independently associated with AF when adjusted for left atrium, LVMI and presence of significant valvular pathology. Genetic predisposition might be underlying the prevalence of acquired AF. Patients with a specific genetic variation in the RAS genes may be more liable to develop AF.https://doi.org/10.1177/1470320311399605 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nurdan Papila Topal Beste Ozben Veysel Sabri Hancer Azra Meryem Tanrikulu Reyhan Diz-Kucukkaya Ali Serdar Fak Yelda Basaran Osman Yesildag |
spellingShingle |
Nurdan Papila Topal Beste Ozben Veysel Sabri Hancer Azra Meryem Tanrikulu Reyhan Diz-Kucukkaya Ali Serdar Fak Yelda Basaran Osman Yesildag Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Nurdan Papila Topal Beste Ozben Veysel Sabri Hancer Azra Meryem Tanrikulu Reyhan Diz-Kucukkaya Ali Serdar Fak Yelda Basaran Osman Yesildag |
author_sort |
Nurdan Papila Topal |
title |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
title_short |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
title_full |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
title_fullStr |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
title_full_unstemmed |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
title_sort |
polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2011-12-01 |
description |
Activation of the renin–angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were consecutively recruited into the study. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and the M235T, A-20C, and G-6A polymorphisms of the angiotensinogen gene were genotyped. Patients with AF had significantly lower frequency of II genotype of ACE I/D and higher frequency of angiotensinogen M235T polymorphism T allele and TT genotype and G-6A polymorphism G allele and GG genotype compared with the controls. AF patients had significantly larger left atrium, higher left ventricular mass index (LVMI) and higher frequency of significant valvular pathology. ACE I/D polymorphism II genotype, angiotensinogen M235T polymorphism TT genotype and G allele and GG genotype of angiotensinogen G-6A polymorphism were still independently associated with AF when adjusted for left atrium, LVMI and presence of significant valvular pathology. Genetic predisposition might be underlying the prevalence of acquired AF. Patients with a specific genetic variation in the RAS genes may be more liable to develop AF. |
url |
https://doi.org/10.1177/1470320311399605 |
work_keys_str_mv |
AT nurdanpapilatopal polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT besteozben polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT veyselsabrihancer polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT azrameryemtanrikulu polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT reyhandizkucukkaya polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT aliserdarfak polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT yeldabasaran polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation AT osmanyesildag polymorphismsoftheangiotensinconvertingenzymeandangiotensinogengeneinpatientswithatrialfibrillation |
_version_ |
1721488557152927744 |