The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies

• Main Authors: Silvana Duran-Ortiz, Alison L. Brittain, John J. Kopchick
• Format: Article
• Language: English
• Published: BMC 2017-06-01
• Series: Clinical Proteomics
• Subjects: Growth hormone; Human proteomics; Mouse proteomics; Aging; GHR−/− mice; bGH mice
• Online Access: http://link.springer.com/article/10.1186/s12014-017-9160-2

Abstract Growth hormone (GH) is a protein that is known to stimulate postnatal growth, counter regulate insulin’s action and induce expression of insulin-like growth factor-1. GH exerts anabolic or catabolic effects depending upon on the targeted tissue. For instance, GH increases skeletal muscle and decreases adipose tissue mass. Our laboratory has spent the past two decades studying these effects, including the effects of GH excess and depletion, on the proteome of several mouse and human tissues. This review first discusses proteomic techniques that are commonly used for these types of studies. We then examine the proteomic differences found in mice with excess circulating GH (bGH mice) or mice with disruption of the GH receptor gene (GHR−/−). We also describe the effects of increased and decreased GH action on the proteome of adult patients with either acromegaly, GH deficiency or patients after short-term GH treatment. Finally, we explain how these proteomic studies resulted in the discovery of potential biomarkers for GH action, particularly those related with the effects of GH on aging, glucose metabolism and body composition.