Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice
Purpose Cognitive impairment is one of the main symptoms of Alzheimer disease and other dementias. Glycyrrhiza uralensis is a natural product that has a protective effect against cognitive impairment. In this study, we investigated whether glycyrrhizic acid, among the main bioactive components of Gl...
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Korean Continence Society
2020-05-01
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doaj-b0e19315b68046b39e2386d3095a8b1c2020-11-25T03:48:33ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312020-05-0124Suppl 1S485510.5213/inj.2040154.077853Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in MiceJu Yeon Ban0Hyun Kyung Park1Su Kang Kim2 Department of Dental Pharmacology, College of Dentistry, Dankook University, Cheonan, Korea Department of Emergency Medicine, Seoul Medical Center, Seoul, Korea Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, KoreaPurpose Cognitive impairment is one of the main symptoms of Alzheimer disease and other dementias. Glycyrrhiza uralensis is a natural product that has a protective effect against cognitive impairment. In this study, we investigated whether glycyrrhizic acid, among the main bioactive components of Glycyrrhiza uralensis, has a neuroprotective effect on scopolamine-induced cognitive impairment. Methods Twenty-week-old male Institute of Cancer Research mice were used in this study. The scopolamine-induced cognitive impairment mice model was used. Glycyrrhizic acid was orally administered to mice once daily for 21 days, while scopolamine (1 mg/kg) treatment was delivered 30 minutes before behavioral tests. Donepezil (2 mg/kg) was used as a positive drug control. To evaluate the effect of glycyrrhizic acid, the following assessments were performed on hippocampal tissue: Y-maze test, acetylcholinesterase activity, antioxidant enzymes’ activity (superoxide dismutase, catalase). Western blotting for phosphor-extracellular signal-regulated kinase, P38, and c-Jun NH2-terminal kinase was conducted. Results We found that glycyrrhizic acid administration significantly improved scopolamine-induced cognitive impairment in the Y-maze test. The acetylcholinesterase activity, superoxide dismutase, and catalase activity in the glycyrrhizic acid-treated group showed a significant reversal of cognitive impairment compared with the scopolamine-treated group. Conclusions Our results suggest that glycyrrhizic acid has a neuroprotective effect on cognitive function in scopolamine-induced cognitive impairment.http://www.einj.org/upload/pdf/inj-2040154-077.pdfmemoryscopolamineglycyrrhizic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju Yeon Ban Hyun Kyung Park Su Kang Kim |
spellingShingle |
Ju Yeon Ban Hyun Kyung Park Su Kang Kim Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice International Neurourology Journal memory scopolamine glycyrrhizic acid |
author_facet |
Ju Yeon Ban Hyun Kyung Park Su Kang Kim |
author_sort |
Ju Yeon Ban |
title |
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice |
title_short |
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice |
title_full |
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice |
title_fullStr |
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice |
title_full_unstemmed |
Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice |
title_sort |
effect of glycyrrhizic acid on scopolamine-induced cognitive impairment in mice |
publisher |
Korean Continence Society |
series |
International Neurourology Journal |
issn |
2093-4777 2093-6931 |
publishDate |
2020-05-01 |
description |
Purpose Cognitive impairment is one of the main symptoms of Alzheimer disease and other dementias. Glycyrrhiza uralensis is a natural product that has a protective effect against cognitive impairment. In this study, we investigated whether glycyrrhizic acid, among the main bioactive components of Glycyrrhiza uralensis, has a neuroprotective effect on scopolamine-induced cognitive impairment. Methods Twenty-week-old male Institute of Cancer Research mice were used in this study. The scopolamine-induced cognitive impairment mice model was used. Glycyrrhizic acid was orally administered to mice once daily for 21 days, while scopolamine (1 mg/kg) treatment was delivered 30 minutes before behavioral tests. Donepezil (2 mg/kg) was used as a positive drug control. To evaluate the effect of glycyrrhizic acid, the following assessments were performed on hippocampal tissue: Y-maze test, acetylcholinesterase activity, antioxidant enzymes’ activity (superoxide dismutase, catalase). Western blotting for phosphor-extracellular signal-regulated kinase, P38, and c-Jun NH2-terminal kinase was conducted. Results We found that glycyrrhizic acid administration significantly improved scopolamine-induced cognitive impairment in the Y-maze test. The acetylcholinesterase activity, superoxide dismutase, and catalase activity in the glycyrrhizic acid-treated group showed a significant reversal of cognitive impairment compared with the scopolamine-treated group. Conclusions Our results suggest that glycyrrhizic acid has a neuroprotective effect on cognitive function in scopolamine-induced cognitive impairment. |
topic |
memory scopolamine glycyrrhizic acid |
url |
http://www.einj.org/upload/pdf/inj-2040154-077.pdf |
work_keys_str_mv |
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