Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease

Nontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance...

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Main Authors: Chin-Chung Shu, Ming-Fang Wu, Sheng-Wei Pan, Ting-Shu Wu, Hsin-Chih Lai, Meng-Chih Lin
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of the Formosan Medical Association
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664620301741
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spelling doaj-b0ee946611c8486a9cccdf328bf779c82020-11-25T02:45:34ZengElsevierJournal of the Formosan Medical Association0929-66462020-06-01119S13S22Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung diseaseChin-Chung Shu0Ming-Fang Wu1Sheng-Wei Pan2Ting-Shu Wu3Hsin-Chih Lai4Meng-Chih Lin5Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Statistical Sciences, Academia Sinica, Taipei, TaiwanDepartment of Chest Medicine, Taipei Veterans General Hospital, Taiwan; School of Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 5, Fuxing St., Guishan Dist., Taoyuan 33305, Taiwan; Corresponding author. Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 5, Fuxing St., Guishan Dist., Taoyuan 33305, Taiwan.Central Research Laboratory, Xiamen Chang Gung Hospital, Xiamen, Fujian, China; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Central Research Laboratory, Xiamen Chang Gung Hospital, Xiamen, Fujian, China, Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanNontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance of secretions, and immune suppression. Specifically, regarding the susceptible host phenotypes without clear pathogenesis, a slender body, pectus excavatum, and postmenopausal female status are common. Also, decreased host immunity to NTM, especially T helper 1 cell responses is frequently observed. Even so, the underlying mechanisms remain unclear and relevant large-scale studies are lacking. Infections due to host genetics associated defects are mostly untreatable but rare in Asia, particularly Taiwan. Nevertheless, some risks for NTM-LD are controllable over disease progression. We suggest that clinicians first manage host factors and deal with the controllable characteristics of NTM-LD, followed by optimizing anti-NTM treatment. Further researches focusing on NTM-LD pathogenesis, especially the host–NTM interaction may advance understanding the nature of the disease and develop efficient therapeutic regimens.http://www.sciencedirect.com/science/article/pii/S0929664620301741Host factorsImmune responseRiskLung diseaseNontuberculous mycobacteria
collection DOAJ
language English
format Article
sources DOAJ
author Chin-Chung Shu
Ming-Fang Wu
Sheng-Wei Pan
Ting-Shu Wu
Hsin-Chih Lai
Meng-Chih Lin
spellingShingle Chin-Chung Shu
Ming-Fang Wu
Sheng-Wei Pan
Ting-Shu Wu
Hsin-Chih Lai
Meng-Chih Lin
Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
Journal of the Formosan Medical Association
Host factors
Immune response
Risk
Lung disease
Nontuberculous mycobacteria
author_facet Chin-Chung Shu
Ming-Fang Wu
Sheng-Wei Pan
Ting-Shu Wu
Hsin-Chih Lai
Meng-Chih Lin
author_sort Chin-Chung Shu
title Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
title_short Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
title_full Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
title_fullStr Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
title_full_unstemmed Host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
title_sort host immune response against environmental nontuberculous mycobacteria and the risk populations of nontuberculous mycobacterial lung disease
publisher Elsevier
series Journal of the Formosan Medical Association
issn 0929-6646
publishDate 2020-06-01
description Nontuberculous mycobacterial lung disease (NTM-LD) prevalence has been increasing over the recent decades. Numerous host factors are associated with NTM-LD development, including susceptible phenotypes such as ciliary defect and lung structural change, pulmonary clearance defect with poor clearance of secretions, and immune suppression. Specifically, regarding the susceptible host phenotypes without clear pathogenesis, a slender body, pectus excavatum, and postmenopausal female status are common. Also, decreased host immunity to NTM, especially T helper 1 cell responses is frequently observed. Even so, the underlying mechanisms remain unclear and relevant large-scale studies are lacking. Infections due to host genetics associated defects are mostly untreatable but rare in Asia, particularly Taiwan. Nevertheless, some risks for NTM-LD are controllable over disease progression. We suggest that clinicians first manage host factors and deal with the controllable characteristics of NTM-LD, followed by optimizing anti-NTM treatment. Further researches focusing on NTM-LD pathogenesis, especially the host–NTM interaction may advance understanding the nature of the disease and develop efficient therapeutic regimens.
topic Host factors
Immune response
Risk
Lung disease
Nontuberculous mycobacteria
url http://www.sciencedirect.com/science/article/pii/S0929664620301741
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