Preliminary study on a polymer carrier containing ginger extract with possible applications in cardiovascular disease

• Main Authors: Livia-Cristina Borcan, Florin Borcan, Mirela Cleopatra Tomescu
• Format: Article
• Language: English
• Published: Victor Babes University of Medicine and Pharmacy Timisoara 2016-12-01
• Series: Research and Clinical Medicine
• Subjects: cardiovascular disease; ginger; nanostructures; polymer carrier.
• Online Access: http://www.resclinmed.eu/public/data_files/articles/43/article_43.pdf

OBJECTIVES AND BACKGROUND The aim of the study was to synthesize and characterize a polyurethane drug delivery system used for a ginger extract with possible applications in cardiovascular disease. MATERIALS AND METHODS The obtained procedure is based on a poly-addition reaction between a diisocyanate and a mixture of polyols and a spontaneous emulsification in the presence of a surfactant. Only aliphatic compounds were used as raw materials and no other chemicals were added as reaction catalyst or promoters. RESULTS Nanostructures sized between 92 and 128 nm, with a medium tendency of agglomeration and very stable to thermal degradation between 30 and 300oC were obtained. We observed the fact that nanostructures’ diluted aqueous solution presents a pH around 6.7 and no evidence of any irritation potential was found after using different assays. CONCLUSIONS The obtained nanostructures can be used as a polymer carrier for ginger extract based on our results. Graphical abstract: Chemical structures of: (a) gingerol, (b) eucalyptol, (c) borneol. REFERENCES 1. Prasad EM, Mopuri R, Islam MS, Kodidhela LD. Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study. Biomed Pharmacother. 2016 [epub ahead of print]. 2. Abdel-Naeem HH, Mohamed HM. Improving the physico-chemical and sensory characteristics of camel meat burger patties using ginger extract and papain. Meat Sci. 2016;118:52-60. 3. Shirpoor A, Rezaei F, Fard AA, Afshari AT, Gharalari FH, Rasmi Y. Ginger extract protects rat’s kidneys against oxidative damage after chronic ethanol administration. Biomed Pharmacother. 2016;84:698-704.