Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study
Objective: To explore impact of Candida on the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome.Methods: A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011–Dec 2016 were enrolled. Data were colle...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-09-01
|
Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.538005/full |
id |
doaj-b0f7e6b2c483411abf5eb3ab58590f2a |
---|---|
record_format |
Article |
spelling |
doaj-b0f7e6b2c483411abf5eb3ab58590f2a2020-11-25T03:55:37ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-09-011010.3389/fcimb.2020.538005538005Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control StudyYi-hui Zuo0Wei-qin Wang1Wei-qin Wang2Qi-jian Chen3Bin Liu4Feng-ying Zhang5Xiao-yan Jin6Jing-qing Hang7Hua-yin Li8Zhi-yao Bao9Zhi-jun Jie10Gui-fang Wang11Xi-wen Gao12He Sun13Jin-fu Xu14Jing Zhang15Jie-ming Qu16Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, School of Medicine, Ruijin North Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Putuo District People's Hospital, Shanghai, ChinaDepartment of Respiratory Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Putuo District People's Hospital, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Fifth' Peoples Hospital, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, Central Hospital of Minhang District, Shanghai, Fudan University, Shanghai, China0Department of Respiratory Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China1Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Respiratory Medicine, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, ChinaObjective: To explore impact of Candida on the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome.Methods: A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011–Dec 2016 were enrolled. Data were collected, including demographic information, conditions during the stable phase of COPD, clinical characteristics of AECOPD, and follow-up information within 1 year after discharge. Univariate analysis and binary logistic regression were applied, and p < 0.05 was regarded as significant.Results: Totally 1,103 patients were analyzed, with 644 lower respiratory airway (LTR) Candida positive cases and 459 Candida negative controls. Long-term prognosis was significantly different between Candida positive and negative group, including the recurrent AECOPD within 180 days (75.5 vs. 6.6%, p < 0.001) and mortality within 1 year (6.9 vs. 0.4%, p < 0.001). Univariate logistic analysis showed that LTR Candida isolation was related to higher recurrence rate of AECOPD within 180 days and mortality within 1 year. Binary logistic regression analysis demonstrated that LTR Candida isolation was independently associated with recurrence of AECOPD within 180 days.Conclusions: LTR Candida isolation was associated with worse long-term prognosis of AECOPD and independently related to higher risks of recurrent AECOPD within 180 days.https://www.frontiersin.org/article/10.3389/fcimb.2020.538005/fullacute exacerbation of chronic obstructive pulmonary disease (AECOPD)prognosisCandidarecurrence of AECOPDmortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-hui Zuo Wei-qin Wang Wei-qin Wang Qi-jian Chen Bin Liu Feng-ying Zhang Xiao-yan Jin Jing-qing Hang Hua-yin Li Zhi-yao Bao Zhi-jun Jie Gui-fang Wang Xi-wen Gao He Sun Jin-fu Xu Jing Zhang Jie-ming Qu |
spellingShingle |
Yi-hui Zuo Wei-qin Wang Wei-qin Wang Qi-jian Chen Bin Liu Feng-ying Zhang Xiao-yan Jin Jing-qing Hang Hua-yin Li Zhi-yao Bao Zhi-jun Jie Gui-fang Wang Xi-wen Gao He Sun Jin-fu Xu Jing Zhang Jie-ming Qu Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study Frontiers in Cellular and Infection Microbiology acute exacerbation of chronic obstructive pulmonary disease (AECOPD) prognosis Candida recurrence of AECOPD mortality |
author_facet |
Yi-hui Zuo Wei-qin Wang Wei-qin Wang Qi-jian Chen Bin Liu Feng-ying Zhang Xiao-yan Jin Jing-qing Hang Hua-yin Li Zhi-yao Bao Zhi-jun Jie Gui-fang Wang Xi-wen Gao He Sun Jin-fu Xu Jing Zhang Jie-ming Qu |
author_sort |
Yi-hui Zuo |
title |
Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study |
title_short |
Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study |
title_full |
Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study |
title_fullStr |
Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study |
title_full_unstemmed |
Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study |
title_sort |
candida in lower respiratory tract increases the frequency of acute exacerbation of chronic obstructive pulmonary disease: a retrospective case-control study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-09-01 |
description |
Objective: To explore impact of Candida on the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome.Methods: A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011–Dec 2016 were enrolled. Data were collected, including demographic information, conditions during the stable phase of COPD, clinical characteristics of AECOPD, and follow-up information within 1 year after discharge. Univariate analysis and binary logistic regression were applied, and p < 0.05 was regarded as significant.Results: Totally 1,103 patients were analyzed, with 644 lower respiratory airway (LTR) Candida positive cases and 459 Candida negative controls. Long-term prognosis was significantly different between Candida positive and negative group, including the recurrent AECOPD within 180 days (75.5 vs. 6.6%, p < 0.001) and mortality within 1 year (6.9 vs. 0.4%, p < 0.001). Univariate logistic analysis showed that LTR Candida isolation was related to higher recurrence rate of AECOPD within 180 days and mortality within 1 year. Binary logistic regression analysis demonstrated that LTR Candida isolation was independently associated with recurrence of AECOPD within 180 days.Conclusions: LTR Candida isolation was associated with worse long-term prognosis of AECOPD and independently related to higher risks of recurrent AECOPD within 180 days. |
topic |
acute exacerbation of chronic obstructive pulmonary disease (AECOPD) prognosis Candida recurrence of AECOPD mortality |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2020.538005/full |
work_keys_str_mv |
AT yihuizuo candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT weiqinwang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT weiqinwang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT qijianchen candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT binliu candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT fengyingzhang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT xiaoyanjin candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT jingqinghang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT huayinli candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT zhiyaobao candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT zhijunjie candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT guifangwang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT xiwengao candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT hesun candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT jinfuxu candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT jingzhang candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy AT jiemingqu candidainlowerrespiratorytractincreasesthefrequencyofacuteexacerbationofchronicobstructivepulmonarydiseasearetrospectivecasecontrolstudy |
_version_ |
1724469147255963648 |