Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer
Distant metastases from papillary thyroid carcinoma (PTC) are rare and are associated with a poor prognosis. Here, we describe a patient with metastatic PTC who was treated with a tyrosine kinase inhibitor (TKI, sorafenib) for several months that was acutely exacerbated by discontinuation. A 43-year...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Academya Publishing Co.
2014-09-01
|
Series: | Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-388.pdf |
id |
doaj-b102f290d9e54d0a93ad5aebc498cf59 |
---|---|
record_format |
Article |
spelling |
doaj-b102f290d9e54d0a93ad5aebc498cf592020-11-24T22:35:20ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782014-09-0129338839310.3803/EnM.2014.29.3.38821197Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid CancerKyung-Jin YunWoohyeon KimEun Hee KimMin-Hee KimDong-Jun LimMoo-Il KangBong-Yun ChaDistant metastases from papillary thyroid carcinoma (PTC) are rare and are associated with a poor prognosis. Here, we describe a patient with metastatic PTC who was treated with a tyrosine kinase inhibitor (TKI, sorafenib) for several months that was acutely exacerbated by discontinuation. A 43-year-old male was diagnosed with PTC in February 2004 and underwent total thyroidectomy followed by two courses of high-dose radioactive iodine (RAI) therapy. Despite two additional courses of high-dose RAI therapy, lung and muscle metastases were developed. Treatment with sorafenib was begun in September 2010. After 11 months treatment of sorafenib, newly developed metastatic lesions were found in mediastinal lymph nodes, liver, and bones. Considered as treatment failure, the administration of sorafenib was discontinued. Two weeks after sorafenib treatment was stopped, the disease progressed abruptly and caused death of the patient by respiratory failure. In our patient, PTC progressed rapidly after the cessation of sorafenib treatment. Patients with several other types of cancer have also experienced such rapid disease progression, termed "flare-ups." Physicians should be aware that flare-ups may occur in advanced PTC patients following the cessation of TKI therapy.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-388.pdfThyroid neoplasmsPapillaryNeoplasm metastasisSorafenib |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyung-Jin Yun Woohyeon Kim Eun Hee Kim Min-Hee Kim Dong-Jun Lim Moo-Il Kang Bong-Yun Cha |
spellingShingle |
Kyung-Jin Yun Woohyeon Kim Eun Hee Kim Min-Hee Kim Dong-Jun Lim Moo-Il Kang Bong-Yun Cha Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer Endocrinology and Metabolism Thyroid neoplasms Papillary Neoplasm metastasis Sorafenib |
author_facet |
Kyung-Jin Yun Woohyeon Kim Eun Hee Kim Min-Hee Kim Dong-Jun Lim Moo-Il Kang Bong-Yun Cha |
author_sort |
Kyung-Jin Yun |
title |
Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer |
title_short |
Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer |
title_full |
Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer |
title_fullStr |
Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer |
title_full_unstemmed |
Accelerated Disease Progression after Discontinuation of Sorafenib in a Patient with Metastatic Papillary Thyroid Cancer |
title_sort |
accelerated disease progression after discontinuation of sorafenib in a patient with metastatic papillary thyroid cancer |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2014-09-01 |
description |
Distant metastases from papillary thyroid carcinoma (PTC) are rare and are associated with a poor prognosis. Here, we describe a patient with metastatic PTC who was treated with a tyrosine kinase inhibitor (TKI, sorafenib) for several months that was acutely exacerbated by discontinuation. A 43-year-old male was diagnosed with PTC in February 2004 and underwent total thyroidectomy followed by two courses of high-dose radioactive iodine (RAI) therapy. Despite two additional courses of high-dose RAI therapy, lung and muscle metastases were developed. Treatment with sorafenib was begun in September 2010. After 11 months treatment of sorafenib, newly developed metastatic lesions were found in mediastinal lymph nodes, liver, and bones. Considered as treatment failure, the administration of sorafenib was discontinued. Two weeks after sorafenib treatment was stopped, the disease progressed abruptly and caused death of the patient by respiratory failure. In our patient, PTC progressed rapidly after the cessation of sorafenib treatment. Patients with several other types of cancer have also experienced such rapid disease progression, termed "flare-ups." Physicians should be aware that flare-ups may occur in advanced PTC patients following the cessation of TKI therapy. |
topic |
Thyroid neoplasms Papillary Neoplasm metastasis Sorafenib |
url |
http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-29-388.pdf |
work_keys_str_mv |
AT kyungjinyun accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT woohyeonkim accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT eunheekim accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT minheekim accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT dongjunlim accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT mooilkang accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer AT bongyuncha accelerateddiseaseprogressionafterdiscontinuationofsorafenibinapatientwithmetastaticpapillarythyroidcancer |
_version_ |
1725723867073216512 |