The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth. This pathway is activated in response to cell cycle arrest signals (cell polarity, transduction, and DNA damage) and limited by growth factors or mitogens asso...
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doaj-b11328f08cbd4ad79e8e0b4d4ee3901d2021-02-05T16:12:46ZengElsevierGenes and Diseases2352-30422021-01-01814860The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasisMohammad Reza Zinatizadeh0Seyed Rouhollah Miri1Peyman Kheirandish Zarandi2Ghanbar Mahmoodi Chalbatani3Catarina Rapôso4Hamid Reza Mirzaei5Mohammad Esmaeil Akbari6Habibollah Mahmoodzadeh7Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding author. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, IranDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Pharmaceutical Sciences State University of Campinas – UNICAMP Campinas, SP, BrazilCancer Research Center, Shohadae Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IranCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding author. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran.Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth. This pathway is activated in response to cell cycle arrest signals (cell polarity, transduction, and DNA damage) and limited by growth factors or mitogens associated with EGF and LPA. The major pathway consists of the central kinase of Ste20 MAPK (Saccharomyces cerevisiae), Hpo (Drosophila melanogaster) or MST kinases (mammalian) that activates the mammalian AGC kinase dmWts or LATS effector (MST and LATS). YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation (TEA domain family, TEAD1-4), stem cells (Oct4 mononuclear factor and SMAD-related TGFβ effector), differentiation (RUNX1), and Cell cycle/apoptosis control (p53, p63, and p73 family members). This is due to the diverse roles of YAP and may limit tumor progression and establishment. TEAD also coordinates various signal transduction pathways such as Hippo, WNT, TGFβ and EGFR, and effects on lack of regulation of TEAD cancerous genes, such as KRAS, BRAF, LKB1, NF2 and MYC, which play essential roles in tumor progression, metastasis, cancer metabolism, immunity, and drug resistance. However, RAS signaling is a pivotal factor in the inactivation of Hippo, which controls EGFR-RAS-RAF-MEK-ERK-mediated interaction of Hippo signaling. Thus, the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer.http://www.sciencedirect.com/science/article/pii/S2352304219301163CancerHippo pathwayMetastasisSignalingTumor suppressor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Rapôso Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh |
spellingShingle |
Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Rapôso Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis Genes and Diseases Cancer Hippo pathway Metastasis Signaling Tumor suppressor |
author_facet |
Mohammad Reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Rapôso Hamid Reza Mirzaei Mohammad Esmaeil Akbari Habibollah Mahmoodzadeh |
author_sort |
Mohammad Reza Zinatizadeh |
title |
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis |
title_short |
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis |
title_full |
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis |
title_fullStr |
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis |
title_full_unstemmed |
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis |
title_sort |
hippo tumor suppressor pathway (yap/taz/tead/mst/lats) and egfr-ras-raf-mek in cancer metastasis |
publisher |
Elsevier |
series |
Genes and Diseases |
issn |
2352-3042 |
publishDate |
2021-01-01 |
description |
Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth. This pathway is activated in response to cell cycle arrest signals (cell polarity, transduction, and DNA damage) and limited by growth factors or mitogens associated with EGF and LPA. The major pathway consists of the central kinase of Ste20 MAPK (Saccharomyces cerevisiae), Hpo (Drosophila melanogaster) or MST kinases (mammalian) that activates the mammalian AGC kinase dmWts or LATS effector (MST and LATS). YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation (TEA domain family, TEAD1-4), stem cells (Oct4 mononuclear factor and SMAD-related TGFβ effector), differentiation (RUNX1), and Cell cycle/apoptosis control (p53, p63, and p73 family members). This is due to the diverse roles of YAP and may limit tumor progression and establishment. TEAD also coordinates various signal transduction pathways such as Hippo, WNT, TGFβ and EGFR, and effects on lack of regulation of TEAD cancerous genes, such as KRAS, BRAF, LKB1, NF2 and MYC, which play essential roles in tumor progression, metastasis, cancer metabolism, immunity, and drug resistance. However, RAS signaling is a pivotal factor in the inactivation of Hippo, which controls EGFR-RAS-RAF-MEK-ERK-mediated interaction of Hippo signaling. Thus, the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer. |
topic |
Cancer Hippo pathway Metastasis Signaling Tumor suppressor |
url |
http://www.sciencedirect.com/science/article/pii/S2352304219301163 |
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