Thermoregulatory Instability in Childhood: Linking the Normal Brain to Hypothalamic Storm

• Main Authors: William Alves Martins, Rafael do Amaral Cristovam, Helena Fussiger, Viviane Maria Vedana, Marta Hemb
• Format: Article
• Language: English
• Published: Hindawi Limited 2016-01-01
• Series: Case Reports in Neurological Medicine
• Online Access: http://dx.doi.org/10.1155/2016/3903854

Central core temperature is tightly controlled by hypothalamic centers, a feature that makes sudden changes in body temperature very unusual. A dysfunction of these hypothalamic pathways leads to Shapiro’s syndrome, comprising spontaneous hypothermia, hyperhidrosis, and corpus callosum dysgenesis. Although it may affect any age, usually it presents in childhood. Variants to this syndrome with completely normal brain anatomy have been consistently reported, expanding the clinical spectrum of the syndrome. Herein, we report the case of a 4-year-old girl with Shapiro’s syndrome and unaffected corpus callosum.